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Gene Information
Gene symbol: ARHGEF11
Gene name: Rho guanine nucleotide exchange factor (GEF) 11
HGNC ID: 14580
Synonyms: KIAA0380, GTRAP48, PDZ-RHOGEF
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | RHOD | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17287471 | ARHGEF11, which encodes the Rho guanine nucleotide exchange factor 11, was analyzed as a positional candidate gene for this linkage because this protein may stimulate Rho-dependent signals, such as the insulin signaling cascade. |
| 2 | 17287471 | These findings suggest that variation within ARHGEF11 nominally increases risk of type 2 diabetes, possibly as a result of increased insulin resistance. |
| 3 | 17369523 | Rho guanine nucleotide exchange factor 11 (ARHGEF11), located on chromosome 1q21, is involved in G protein signaling and is a pathway known to play a role in both insulin secretion and action. |
| 4 | 21246010 | The human Rho guanine nucleotide exchange factor 11 (ARHGEF11) functions as an activator of Rho GTPases and is thought to influence insulin signaling. |