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Gene Information
Gene symbol: ARHGEF2
Gene name: Rho/Rac guanine nucleotide exchange factor (GEF) 2
HGNC ID: 682
Synonyms: LFP40, GEF-H1, KIAA0651, P40
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | CYBB | 1 hits |
| 3 | PIK3CA | 1 hits |
| 4 | RAB10 | 1 hits |
| 5 | SLC2A4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19175688 | Diabetes was characterized by increased myocardial, liver and serum XO activity (but not expression), increased myocardial ROS generation, p22(phox), p40(phox), p47(phox), p91(phox) mRNA expression, iNOS (but not eNOS) expression, NT generation, caspase 3/7 and PARP activity/expression, chromatin fragmentation and fibrosis (enhanced accumulation of collagen, TGF-beta, CTGF and fibronectin), and declined systolic and diastolic myocardial performance. |
| 2 | 20816670 | On molecular assay, 8-OHdG antagonized the action of GTP on Rac, a small GTP binding protein, without affecting Rac-guanosine exchange factor (GEF) or phosphoinositide 3-kinases (PI3K) activity. |
| 3 | 21081706 | Sitagliptin also reduced adipocyte mRNA expression of inflammatory genes, including IL-6, TNF?, IL-12(p35), and IL-12(p40), 2.5- to fivefold as well as 12-lipoxygenase protein expression. |
| 4 | 21454697 | This process is expected to require the participation of a guanine nucleotide exchange factor (GEF) to generate the GTP-bound form of Rab10, but this GEF has not hitherto been identified. |
| 5 | 21454697 | The present study identifies Dennd4C, a recently described GEF for Rab10, as the primary GEF required for GLUT4 translocation. |