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Gene Information
Gene symbol: ASIP
Gene name: agouti signaling protein
HGNC ID: 745
Synonyms: ASP
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | MC1R | 1 hits |
| 3 | MC4R | 1 hits |
| 4 | MGRN1 | 1 hits |
| 5 | PIK3CA | 1 hits |
| 6 | PNPLA3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17088412 | To examine adiponutrin regulation by the insulin pathway in relation to other WAT-related proteins with well-known relation to insulin signaling and action, we examined in healthy young men (1) the association of adiponutrin with p85alpha PI3K and HKII, leptin, adiponectin, and acylation-stimulating protein (ASP) and (2) the regulation of adiponutrin and WAT-derived proteins by 3-h hyperinsulinemic euglycemic clamp (HIEG). |
| 2 | 21460229 | These mutations have been described as suppressors of ASP action, blocking its antagonizing effects on the melanocortin 1 and 4 receptors (MC1R and MC4R) in the skin and the brain, respectively, via unknown mechanisms. |
| 3 | 21460229 | We show that overexpression of ASP inhibits the rise in cAMP levels in response to ?-melanocyte-stimulating hormone, an MC4R agonist, by blocking ligand binding and by directing MC4R trafficking to the lysosome. |
| 4 | 21460229 | Loss-of-function of either attractin or MGRN1 blocks ASP-dependent MC4R degradation and promotes increased trafficking of internalized MC4R to the cell surface, but it does not restore ?-melanocyte-stimulating hormone-dependent cAMP signaling. |