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Gene Information
Gene symbol: ATF4
Gene name: activating transcription factor 4 (tax-responsive enhancer element B67)
HGNC ID: 786
Synonyms: TAXREB67, CREB-2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | APOE | 1 hits |
| 2 | ATF3 | 1 hits |
| 3 | CALR | 1 hits |
| 4 | CANX | 1 hits |
| 5 | CREB1 | 1 hits |
| 6 | EIF2S1 | 1 hits |
| 7 | EIF4EBP1 | 1 hits |
| 8 | FGF2 | 1 hits |
| 9 | LPIN2 | 1 hits |
| 10 | MAPK1 | 1 hits |
| 11 | PIK3CA | 1 hits |
| 12 | PMAIP1 | 1 hits |
| 13 | TLR2 | 1 hits |
| 14 | TRIB3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 22028770 | At molecular level, polymorphism -491A/T and ATF4 elicit independent control of APOE gene expression. |
| 2 | 16246168 | Accompanying this general protein synthesis control, eIF2 phosphorylation induces translation of specific mRNAs, such as that encoding the bZIP (basic leucine zipper) transcriptional regulator ATF4 (activating transcription factor 4). |
| 3 | 16246168 | ATF4 also enhances the expression of additional transcription factors, ATF3 and CHOP (CCAAT/enhancer-binding protein homologous protein)/GADD153 (growth arrest and DNA-damage-inducible protein), that assist in the regulation of genes involved in metabolism, the redox status of the cells and apoptosis. |
| 4 | 18316032 | The Eif4ebp1 gene encoding 4E-BP1 was revealed to be a direct target of the transcription factor ATF4. |
| 5 | 19164757 | We show that ATF3 and ATF4 form a complex capable of binding to the NOXA promoter, which is required for NOXA activation. |
| 6 | 20589738 | The Eif4ebp1 gene, encoding 4E-BP1, is a direct target of a transcription factor activating transcription factor-4 (ATF4), a master regulator of gene expression in stress responses. |
| 7 | 20933500 | Overexpression and knockdown experiments showed the importance of activating transcription factor 4 (ATF4), an ER stress-induced transcription factor, in the induction of TLR2 expression during ER stress. |
| 8 | 20933500 | This was confirmed by the increased expression and function of TLR2 during treatment with salubrinal, an activator of ATF4 pathway. |
| 9 | 21357464 | Transcriptional activation of LIPIN2 by ER stress is mediated by activating transcription factor 4, as demonstrated by LIPIN2 promoter assays, Western blot analyses, and chromatin immunoprecipitation assays. |
| 10 | 20306012 | ATF4 is induced in aortic smooth muscle cells by fibroblast growth factor 2 and in the intact vessel wall following balloon angioplasty. |
| 11 | 21475143 | Examined were the effects of intravenously infused glucose and/or lipids on proximal ER stress sensor activation (PERK, eIF2-?, ATF4, Xbox protein 1 (XBP1s)), unfolded protein response (UPR) proteins (GRP78, calnexin, calreticulin, protein disulphide isomerase (PDI), stress kinases (JNK, p38 MAPK) and insulin signaling (insulin/receptor substrate (IRS) 1/2 associated phosphoinositol-3-kinase (PI3K)) in rat liver. |
| 12 | 20592469 | Further analysis in MIN6 cells demonstrated that TRB3 interacted with the transcription factor ATF4 and that this complex acted as a competitive inhibitor of cAMP response element-binding (CREB) transcription factor in the regulation of key exocytosis genes. |