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Gene Information
Gene symbol: ATM
Gene name: ataxia telangiectasia mutated
HGNC ID: 795
Synonyms: TEL1, TELO1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | CHEK2 | 1 hits |
| 3 | H2AFX | 1 hits |
| 4 | HIF1A | 1 hits |
| 5 | INS | 1 hits |
| 6 | RAD51 | 1 hits |
| 7 | TP53 | 1 hits |
| 8 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 9398851 | Atm is required for proper assembly of Rad51 onto the chromosomal axial elements during meiosis. |
| 2 | 20208057 | ATM, mutated in ataxia telangiectasia, is critical for the genotoxic stress response, and its deficiency is associated with accelerated atherosclerosis and insulin resistance in humans and mice. |
| 3 | 20357360 | In obese women, CD11c(+) ATM density was greater in subcutaneous than omental adipose tissue and correlated with markers of insulin resistance. |
| 4 | 20357360 | Tissue culture medium conditioned by CD11c(+) ATMs, but not CD11c(-) ATMs or other stromovascular cells, impaired insulin-stimulated glucose uptake by human adipocytes. |
| 5 | 20736911 | This phosphorylation of H2AX is mediated by the phosphatidyl-inosito 3-kinase (PI3K) family of proteins, ataxia telangiectasia mutated (ATM), DNA-protein kinase catalytic subunit and ATM and RAD3-related (ATR). |
| 6 | 20956556 | ATM phosphorylates the p53 tumor suppressor on a site (Ser15) that regulates transcription activity. |
| 7 | 20956556 | This analysis demonstrates that p53 phosphorylation on an ATM site is an important mechanism in the physiological regulation of glucose homeostasis. |
| 8 | 21315178 | Particular attention is given to the role of ATM in insulin signaling and Akt activation. |
| 9 | 15187252 | The checkpoint kinase Chk2 is activated in response to DNA damage through pathways requiring protein kinases ATM and/or ATR. |
| 10 | 18534819 | The role of ATM in activation of Akt was further confirmed in mouse embryonic fibroblast (MEF) A29 (ATM+/+) and A38 (ATM-/-) cells. |
| 11 | 20676049 | In different cellular models where ATM expression was disrupted, we demonstrated that the absence of ATM leads to an increased expression of both subunits of the transcription factor Hypoxia Inducible Factor 1 (HIF-1). |
| 12 | 20676049 | Interestingly, we demonstrated that ATM disruption positively regulates both expression and function of the basal glucose transporter GLUT-1 as well as the proangiogenic factor, VEGF. |
| 13 | 20676049 | In addition, our results suggest that the absence of ATM increases HIF-1 proteins biosynthesis, and this effect is dependant on the oxidative stress existing in ATM deficient cells. |