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Gene Information
Gene symbol: BACE1
Gene name: beta-site APP-cleaving enzyme 1
HGNC ID: 933
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | APLP2 | 1 hits |
| 2 | INS | 1 hits |
| 3 | PRKAA1 | 1 hits |
| 4 | PSEN1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19117266 | BACE2 is a protease homologous to BACE1 protein, an enzyme involved in the amyloid formation of Alzheimer disease (AD). |
| 2 | 20819221 | In contrast, we detected little change in Alzheimer A? precursor protein expression, or BACE1 and Presenilin 1 levels. |
| 3 | 20943756 | Intracellular analysis using immunofluorescence showed colocalization of BACE1 with insulin and BACE2 with clathrin-coated vesicles of the plasma membrane in MIN6 cells. |
| 4 | 19237574 | Finally, inhibition of AMP-activated protein kinase (AMPK) by the pharmacological inhibitor Compound C largely suppresses metformin's effect on Abeta generation and BACE1 transcription, suggesting an AMPK-dependent mechanism. |