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Gene Information
Gene symbol: BAD
Gene name: BCL2-associated agonist of cell death
HGNC ID: 936
Synonyms: BCL2L8, BBC2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BCL2 | 1 hits |
| 2 | BCL2L11 | 1 hits |
| 3 | CASP3 | 1 hits |
| 4 | FOXO1 | 1 hits |
| 5 | IRS1 | 1 hits |
| 6 | IRS2 | 1 hits |
| 7 | PCNA | 1 hits |
| 8 | PI3 | 1 hits |
| 9 | TRPC3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 22140505 | Confocal microscopy, real-time PCR and western blotting analyses revealed increased expression of PCNA and down-regulation of p27-Kip1 and altered expression of insulin receptors, insulin receptor substrate-2 and phosphorylated BAD. |
| 2 | 19114643 | In vivo MR antagonist treatment promoted antiapoptotic effects by increasing phosphorylation of BAD serine(136) and expression of Bcl-2 and Bcl-xL, decreasing cytochrome c release and BAD expression, and suppressing caspase-3 activation. |
| 3 | 21354306 | IRS overexpression increased MnSOD abundance as well as BAD phosphorylation while Bim and BAX levels remained unchanged. |
| 4 | 21354306 | Thus, overexpression of both IRS-1 and IRS-2 induces complete resistance to glucose-induced caspase-3 activation via PI3-kinase mediated BAD phosphorylation and MnSOD expression independent of FoxO1. |
| 5 | 21684255 | Treatment of TRPC3(+/+) macrophages with the pro-apoptotic cytokine TNF? induced time-dependent phosphorylation of I?B?, AKT and BAD, and this was drastically reduced in TRPC3(-/-) macrophages. |