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Gene Information
Gene symbol: BCL2A1
Gene name: BCL2-related protein A1
HGNC ID: 991
Synonyms: GRS, BFL1, BCL2L5, ACC-1, ACC-2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACACA | 1 hits |
| 2 | CPT1A | 1 hits |
| 3 | INS | 1 hits |
| 4 | MLXIPL | 1 hits |
| 5 | NFKB1 | 1 hits |
| 6 | PRKAA1 | 1 hits |
| 7 | SNF1LK2 | 1 hits |
| 8 | STEAP4 | 1 hits |
| 9 | UCP2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15934915 | Studies in ACC2 knockout mice and in experimental animals treated with isozyme-nonselective ACC inhibitors have demonstrated the potential for treating metabolic syndrome through this modality. |
| 2 | 16485039 | These studies suggest that pharmacological inhibition of Acc1 and -2 may be a novel approach in the treatment of NAFLD and hepatic insulin resistance. |
| 3 | 17526931 | These changes were associated with reduced expression of lipogenic genes (SREBP1c, ACC1, SCD1, and mtGPAT) and increased expression of oxidative/thermogenic genes (CPT1 and UCP2). |
| 4 | 18239551 | Overexpression of SIK2 repressed the expression of lipogenic genes, including FAS, acetyl CoA carboxylase 2 (ACC2), and stearoyl CoA desaturase 1 (SCD1), and reduced triglyceride content. |
| 5 | 18239551 | Reduction of endogenous SIK2 expression through RNA interference increased the expression of FAS, ACC2, and SCD1. |
| 6 | 18381287 | To investigate the effects of ACC1 inhibition on insulin secretion, three small interfering RNA (siRNA) duplexes targeting ACC1 (siACC1) were transfected into the INS-1-derived cell line, 832/13; the most efficacious duplex was also cloned into an adenovirus and used to transduce isolated rat islets. |
| 7 | 19343319 | In addition to the upregulation of known pro-apoptotic genes, a number of anti-apoptotic genes including BIRC3, BCL2A1, TNFAIP3, CFLAR and TRAF1 were induced by cytokines through NF-kappaB. |
| 8 | 19688337 | The AMP-activated protein kinase (AMPK) regulates lipid oxidation in muscle by inhibiting acetyl-CoA carboxylase-2 (ACC2) and increasing mitochondrial biogenesis. |
| 9 | 20303812 | An adipogenic medium stimulated moderate FAS and ACC1 expression in cells from both diabetic and non-diabetic animals, but glucose and insulin on their own had no such stimulatory action. |
| 10 | 19727214 | Consistent with increased nuclear ChREBP levels, expressions of ChREBP target genes involved in lipogenesis including Acc-1, Fas and Gpat were upregulated by 2-fold(P<0.05),1.7-fold (P<0.05) and 4.2-fold(P<0.05), respectively, in db/db mice. |
| 11 | 21849520 | In addition, STAMP2 gene expression was positively associated with lipogenic (FASN, ACC1, SREBP1, THRSP14, TR?, and TR?1), CAV1, IRS1, GLUT4, and CD206 gene expression. |