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Gene Information
Gene symbol: BCL2L1
Gene name: BCL2-like 1
HGNC ID: 992
Synonyms: BCLX, BCL2L, Bcl-X, bcl-xL, bcl-xS, PPP1R52
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BAX | 1 hits |
| 2 | BBC3 | 1 hits |
| 3 | BCL2 | 1 hits |
| 4 | EPO | 1 hits |
| 5 | FAS | 1 hits |
| 6 | FASLG | 1 hits |
| 7 | GAPDH | 1 hits |
| 8 | GHRL | 1 hits |
| 9 | HMOX1 | 1 hits |
| 10 | HSPA1A | 1 hits |
| 11 | INS | 1 hits |
| 12 | MCL1 | 1 hits |
| 13 | PDX1 | 1 hits |
| 14 | PTGDS | 1 hits |
| 15 | SOCS3 | 1 hits |
| 16 | STAT3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11899074 | The delivery of transgenes capable of interfering with antigenic recognition and/or cell death [e.g., Fas ligand (FasL), Bcl-2, Bcl-XL] as well as imparting tolerance/immunoregulation [e.g., interleukin(IL)-4, IL-10, transforming growth factor (TGF)-beta], or cytoprotection [e.g., heme oxygenase-1 (HO-1), catalase, manganese superoxide dismutase (MnSOD)] may prevent recurrent type 1 diabetes in islet transplantation and offer a promising form of immunotherapy. |
| 2 | 12663450 | The expression of Nix and Bcl-xL proteins decreased relative to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) control on the removal of erythropoietin (EPO) from the culture medium. |
| 3 | 17047923 | The concentration of anti-apoptotic heat shock protein (HSP) 70 in DRG was decreased, whereas concentrations of Bcl-xl and HSP27 were unaltered. |
| 4 | 17562326 | The islets from cKO mice demonstrated hyperactivation of STAT3 and higher induction of Bcl-xL than did islets from WT mice, and SOCS3-deficient beta-cells were more resistant to apoptosis induced by STZ in vitro than were WT beta-cells. |
| 5 | 17870134 | Our findings suggest that streptozotocin-induced diabetes increases apoptotic cell death in testis tissue through the up-and down-regulation of Bcl-2 family proteins and the interaction of Bad and Bcl-X(L). |
| 6 | 17883332 | Selective expression of HO-1 prevented TNF- and hyperglycemia-mediated superoxide (O2-) formation, DNA degeneration, and upregulation of caspase, but increased the expression of pAkt and Bcl-xL, proteins responsible for endothelial dysfunction in diabetes. |
| 7 | 20421300 | The antiapoptotic Bcl-XL protein is localized mainly at the mitochondria of the beta-cells and antagonizes PUMA action, but Bcl-XL is inactivated by the BH3-only sensitizer DP5/Hrk in cytokine-exposed beta-cells. |
| 8 | 21139139 | This resistance to apoptosis was associated with decreased abundance of the proapoptotic protein Bax and increases in abundance of the antiapoptotic proteins Bcl-2, Bcl-xL, XIAP, and Flip. |
| 9 | 20031167 | Increased Bax, Daxx, and JNK mRNA expression and decreased Bcl X(L) expression in insulin-deficient rats, led to increased hepatocyte apoptosis than normal rats. |
| 10 | 20798690 | All cytotoxic stresses rapidly and preferentially decreased Mcl-1 protein expression as compared with the late effect observed on the other antiapoptotic proteins, Bcl-2 and Bcl-xL. |
| 11 | 20973890 | Genes encoding pro-apoptotic effectors, like Tnfrsf5, Bid3 and Bcl2l1, were also upregulated in diabetic rats and attenuated in erythropoietin-treated group. |
| 12 | 12697734 | Bcl(XL) and Bcl-2 expression were reduced in Pdx1(+/-) islets. |
| 13 | 12684506 | L-PGDS (50 microg/ml) was able to significantly inhibit VSMC proliferation and DNA synthesis and induce the apoptotic genes bax, bcl-x, and ei24 in SHR but had no effect on WKY cells. |
| 14 | 22005105 | We found that learning and memory level in the ghrelin treatment group improved significantly, expression of Bcl-xl, BDNF, CREB, p-CREB, and p-ERK1/2 in the hippocampus was increased in the ghrelin treatment group, and the number of apoptotic neurons in the hippocampus decreased remarkably. |