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Gene Information

Gene symbol: BDKRB2

Gene name: bradykinin receptor B2

HGNC ID: 1030

Synonyms: BK-2

Related Genes

#	Gene Symbol	Number of hits
1	ACE	1 hits
2	CCL2	1 hits
3	IL6	1 hits
4	NOS3	1 hits

Related Sentences

#	PMID	Sentence
1	18367657	To investigate the impact of bradykinin B(2) receptor (B2R) activation during ACE inhibition, type II diabetic mice (C57BLKS db/db) received for 20 wk: 1) ACEi (ramipril) alone, 2) ACEi + HOE-140 (a specific B2R antagonist), 3) HOE-140 alone, or 4) no treatment.
2	20489655	The experimental results showed that the cytotoxic effects of Ang II on human umbilical vein endothelial cells were significantly ameliorated by atorvastatin pretreatment (LDH tests, MTT assay, and propdium iodide (PI)/Annexin V-stating analysis), and atorvastatin treatment simultaneously enhanced expression of endothelial nitric oxide synthase and yielded of nitric oxide (NO) and cyclic guanosine monophosphate, but both effects were attenuated by the B2Rs antagonist HOE-140.
3	21659767	For a detrimental role of the KKS, BK upregulates tubular cell IL-6, CCL-2, and TGF-? expression via ERK1/2 activation; the B2R-/- status protects against the development of DN lesions in STZ-injected mice, while blocking B2R with icatibant alleviates biochemical and histologic injuries in uninephrectomized db/db mice.