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Gene Information
Gene symbol: BMP3
Gene name: bone morphogenetic protein 3
HGNC ID: 1070
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FOXM1 | 1 hits |
| 2 | HNF1A | 1 hits |
| 3 | INS | 1 hits |
| 4 | SMAD2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21628466 | Twenty-four hours after induction of the mutant HNF1A protein, we identified a prominent down-regulation of the bone morphogenetic protein 3 gene (Bmp-3) mRNA expression. |
| 2 | 21628466 | Interestingly, treatment of naïve INS-1 cells or murine organotypic islet cultures with recombinant human BMP-3 potently increased their insulin levels and restored the decrease in SMAD2 phosphorylation and insulin gene expression induced by the HNF1A frameshift mutation. |
| 3 | 21628466 | Our study suggests a critical link between HNF1A-MODY-induced alterations in Bmp-3 expression and insulin gene levels in INS-1 cells and indicates that the reduced expression of growth factors involved in tissue differentiation may play an important role in the pathophysiology of HNF1A-MODY. |