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Gene Information
Gene symbol: BTG2
Gene name: BTG family, member 2
HGNC ID: 1131
Synonyms: PC3, TIS21, MGC126063, MGC126064
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | POMC | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8382698 | The in vitro processing of mPOMC by the insulin secretory granule endopeptidase activity reported here is in excellent agreement with the in vivo processing of this prohormone by a combination of PC2 and PC3, candidates of prohormone endpeptidase, in gene transfer studies with cells that express the regulated secretory pathway (Thomas, L., Leduc, R., Thorne, B. |
| 2 | 8138054 | PC3 cleaves proinsulin first to generate a proinsulin conversion intermediate that is the preferred substrate of PC2. |
| 3 | 8138054 | Both PC2 and PC3 activities are influenced by Ca2+ and pH, but the more stringent Ca2+ and pH requirements of PC3 suggest it as the most likely enzyme to regulate proinsulin conversion, as well as initiate it. |