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Gene Information
Gene symbol: C12orf5
Gene name: chromosome 12 open reading frame 5
HGNC ID: 1185
Synonyms: TIGAR
Related Genes
Related Sentences
# |
PMID |
Sentence |
1 |
21185935
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In vitro data indicate that cellular levels of reactive oxygen species depend on the expression and activity of p53, which plays a key role in energy metabolism and as a crucial transcription factor for SCO cytochrome oxidase deficient homolog 2 (SCO2) and tumor p53-induced glycolysis and apoptosis regulator (TIGAR), which regulate mitochondrial respiration and glycolysis in cells.
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2 |
21185935
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Exercise training decreased p53 protein levels and TIGAR expression in skeletal muscle (P<0.05), but SCO2 expression was unchanged.
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