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Gene Information
Gene symbol: CAMK2G
Gene name: calcium/calmodulin-dependent protein kinase II gamma
HGNC ID: 1463
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | CREB1 | 1 hits |
| 3 | IGF1R | 1 hits |
| 4 | INS | 1 hits |
| 5 | NOS2A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19545622 | Because the effect of CaM is mediated through CaM-dependent protein kinase II (CaMKII), we have investigated here the potential role of CaMKII in H(2)O(2)-induced ERK1/2 and PKB phosphorylation by using pharmacological inhibitors of CaM and CaMKII, a CaMKII inhibitor peptide, and siRNA knockdown strategies for CaMKII alpha. |
| 2 | 19545622 | These results demonstrate that CaMKII plays a critical upstream role in mediating the effects of H(2)O(2) on ERK1/2, PKB, and IGF-1R phosphorylation. |
| 3 | 20215576 | These results demonstrate that CaMKII does not regulate insulin-stimulated glucose uptake in skeletal muscle. |
| 4 | 21301804 | Cyclic AMP response element-binding protein (CREB) stimulates beta cell Irs2 expression and is a major calcium/calmodulin-dependent kinase (CaMK)(IV) target in neurons. |
| 5 | 21301804 | We therefore hypothesised that CaMK(IV) mediates glucose-induced Irs2 expression in beta cells via CREB activation. |
| 6 | 21301804 | Similarly, overproduction of a constitutively active form of CaMK(IV) promoted sustained CREB phosphorylation and a significant increase in Irs2 but not Irs1 expression. |
| 7 | 21301804 | Finally, overproduction of a dominant negative form of CREB completely suppressed glucose and CaMK(IV) stimulation of Irs2 expression. |
| 8 | 21331776 | The aim of this study was to investigate whether CaMKII affects iNOS-mediated pericyte death in the retina of diabetic mice with early stage disease. |
| 9 | 21331776 | Total- and phospho-CaMKII, iNOS, and active caspase-3 protein levels were assessed by Western blotting, and CaMKII activity was measured by kinase assay. iNOS-related pericyte death was assessed by double immunofluorescent staining for iNOS and ?-smooth muscle actin, followed by the TUNEL assay. |
| 10 | 21331776 | Our results demonstrate that CaMKII contributes to iNOS-related death of pericytes in the diabetic retina and that inactivation of this enzyme may be a potential treatment for retinal vascular lesion. |