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Gene Information
Gene symbol: CASP1
Gene name: caspase 1, apoptosis-related cysteine peptidase
HGNC ID: 1499
Synonyms: ICE
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | CLEC7A | 1 hits |
| 3 | IFNG | 1 hits |
| 4 | IL18 | 1 hits |
| 5 | IL1B | 1 hits |
| 6 | NOS2A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11108714 | IL-1beta is synthesized as an inactive precursor protein that requires cleavage by the IL-1beta-converting enzyme (ICE) for activation. dsRNA and IFN-gamma stimulate IL-1beta expression and ICE activation in primary beta-cells, respectively. |
| 2 | 11108714 | Selective ICE inhibition attenuates dsRNA + IFN-gamma-induced iNOS expression by primary beta-cells. |
| 3 | 20588114 | Caspase-1 is required for IL-1beta activity and the release of free fatty acids from the adipocyte. |
| 4 | 20185806 | CD11c(+) eATMPhis expressed a mixed M1/M2 profile, with some M1 transcripts upregulated (IL-12p40 and IL-1beta), others downregulated (iNOS, caspase-1, MCP-1, and CD86), and multiple M2 and matrix remodeling transcripts upregulated (arginase-1, IL-1Ra, MMP-12, ADAM8, VEGF, and Clec-7a). |
| 5 | 21884175 | Inflammasome assembly results in caspase-1 activation, which in turn drives maturation and secretion of the pro-inflammatory cytokines interleukin 1? (IL-1?) and IL-18, and induces pyroptosis to eliminate the infectious agent. |
| 6 | 10690898 | Cytokine-induced NO-independent ICE transcription was confirmed using iNOS inhibitors. |
| 7 | 10690898 | Exposure of rat and mouse islets, or rat insulinoma cells, for 24 h to IFNgamma alone or in combination with the two other cytokines also resulted in a highly significant ICE mRNA expression. |