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Gene Information
Gene symbol: CBLB
Gene name: Cbl proto-oncogene, E3 ubiquitin protein ligase B
HGNC ID: 1542
Synonyms: RNF56, Cbl-b
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GAB2 | 1 hits |
| 2 | IRS1 | 1 hits |
| 3 | LEP | 1 hits |
| 4 | MS4A2 | 1 hits |
| 5 | RAC1 | 1 hits |
| 6 | SYK | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16002993 | Ubiquitin-protein ligase Cbl-b negatively regulates high affinity IgE receptor (FcepsilonRI)-mediated degranulation and cytokine gene transcription in mast cells. |
| 2 | 16002993 | FcepsilonRI-mediated tyrosine phosphorylation of Syk, Gab2, and phospholipase C-gamma1, and activation of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase (MAP kinase), and inhibitor of nuclear factor kappaB kinase (IKK), and generation of Rac1 are unaffected in cells overexpressing the truncated Cbl-b in the lipid raft. |
| 3 | 17601987 | Co-culture of Cbl-b(-/-) macrophages with 3T3-L1 adipocytes induced leptin expression and dephosphorylation of insulin receptor substrate 1, leading to impaired glucose uptake in adipocytes. |