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Gene Information
Gene symbol: CBX4
Gene name: chromobox homolog 4
HGNC ID: 1554
Synonyms: hPC2, PC2, NBP16
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CPE | 1 hits |
| 2 | INS | 1 hits |
| 3 | PAX6 | 1 hits |
| 4 | POMC | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 1478377 | Cleavage of proinsulin is mediated by at least two prohormone convertases (PC3/PC1 and PC2). |
| 2 | 8382698 | The in vitro processing of mPOMC by the insulin secretory granule endopeptidase activity reported here is in excellent agreement with the in vivo processing of this prohormone by a combination of PC2 and PC3, candidates of prohormone endpeptidase, in gene transfer studies with cells that express the regulated secretory pathway (Thomas, L., Leduc, R., Thorne, B. |
| 3 | 8138054 | Both PC2 and PC3 activities are influenced by Ca2+ and pH, but the more stringent Ca2+ and pH requirements of PC3 suggest it as the most likely enzyme to regulate proinsulin conversion, as well as initiate it. |
| 4 | 15618358 | We conclude that lack of CPE in islet beta-cells results in a marked decrease in processing of proIAPP at its NH(2) (but not COOH) terminus that is associated with attenuated levels of PC2 and (pro)7B2 and a great reduction in formation of mature amidated IAPP. |
| 5 | 20592023 | In primary rat ? cells, we confirm that Pax6 controls the transcription of the Proglucagon and processing enzyme PC2 genes and identify three new target genes coding for MafB, cMaf, and NeuroD1/Beta2, which are all critical for Glucagon gene transcription and ? cell differentiation. |