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Gene Information
Gene symbol: CCND2
Gene name: cyclin D2
HGNC ID: 1583
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCK | 1 hits |
| 2 | CCND1 | 1 hits |
| 3 | CDC2 | 1 hits |
| 4 | CDK2 | 1 hits |
| 5 | CDKN1A | 1 hits |
| 6 | CDKN2A | 1 hits |
| 7 | PRL | 1 hits |
| 8 | PTHLH | 1 hits |
| 9 | UCP2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15831479 | In adult murine islets basal cyclin D2 mRNA expression was easily detected, while cyclin D1 was expressed at lower levels and cyclin D3 was nearly undetectable. |
| 2 | 18845673 | Analysis of cyclin and cdk mRNA and protein abundance revealed that CCK overexpression increased cyclin A, cyclin B, cyclin E, cdk1, and cdk2 with no change in cyclin D1, cyclin D2, cyclin D3, cdk4, or cdk6 in mouse and human islets. |
| 3 | 19343564 | It is established that beta-cell replication is associated with increased cyclin D1 and CDK4 levels; deficiency in CDK4 or cyclin D2 results in reduced beta-cell mass and diabetes. |
| 4 | 21239441 | An ad-small interfering RNA specific for cyclin D2 attenuates markedly the effects of PRL on islet DNA synthesis. |
| 5 | 21357466 | Consistent with a dramatic decrease in ?-cell mass and reduced ?-cell proliferation, lower expression of cyclin D2 and pancreatic duodenal homeobox-1, two key regulators of proliferation, was observed, whereas expression of the cell cycle inhibitor p21, a p53 target gene, was increased. |
| 6 | 21321094 | Proliferation (cyclin D2, Ccnd2) and anti-apoptosis (Tnfaip3) genes had increased expression in Ucp2(-/-) islets, whereas the mRNA of pro-apoptosis genes (Jun, Myc) was reduced. |
| 7 | 21800111 | Analysis of islet G1/S cell cycle proteins revealed that chronic overabundance of PTHrP(1-139) in the beta cell significantly increased the cell cycle activator cyclin D2 and decreased levels of cyclin-dependent kinase 4 inhibitor (p16( Ink4a ) [Ink4a also known as Cdkn2a]), but acute treatment with PTHrP(1-36) did not. |