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Gene Information
Gene symbol: CD28
Gene name: CD28 molecule
HGNC ID: 1653
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | CASP8 | 1 hits |
| 3 | CD55 | 1 hits |
| 4 | CD86 | 1 hits |
| 5 | CTLA4 | 1 hits |
| 6 | CX3CR1 | 1 hits |
| 7 | IDDM2 | 1 hits |
| 8 | MAPK1 | 1 hits |
| 9 | TPT1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21873805 | The expression of CX3CR1 was largely restricted to those CD4(+) cells that lacked CD28 co-stimulatory molecule. |
| 2 | 7532678 | Female NOD mice treated at the onset of insulitis (2-4 wk of age) with CTLA4Ig immunoglobulin (Ig) (a soluble CD28 antagonist) or a monoclonal antibody (mAb) specific for B7-2 (a CD28 ligand) did not develop diabetes. |
| 3 | 9410902 | Our data support the hypothesis that a CD28 signal is requisite for activation of IL-4-producing cells and protection from IDDM. |
| 4 | 11927616 | In addition, we observed different effects with selective blockade of either B7-1 or B7-2 molecules; B7-1 appears to deliver a negative signal by engaging CTLA-4, while B7-2 engagement of CD28 upregulates T cell proliferation and cytokine secretion. |
| 5 | 15163118 | After Fas triggering, the generation of the active sub-units of caspase-8 is significantly reduced in T1DM T-cells restimulated via TCR/CD3 and/or CD28. |
| 6 | 15972645 | CTLA-4 binding to B7-1/B7-2 is believed to be crucial for its inhibitory signal both by competing for CD28 binding to the same ligands and aggregating CTLA-4 to deliver negative signals. |
| 7 | 16886063 | However, it has been difficult to explore the biology of selective engagement of CTLA-4 in vivo because CTLA-4 shares its ligands, B7-1 and B7-2, with CD28. |
| 8 | 18178847 | In the case of DAF, differential expression of mRNA was extended to the protein level; NOD CD4+ T cells expressed higher levels of cell surface DAF compared with NOD.Idd3/5 CD4+ T cells following activation with anti-CD3 and -CD28. |
| 9 | 19144262 | Since CD28 co-stimulation is essential for the survival of CD4+CD25high T cells, we determined whether CD28-upregulated translationally controlled tumor protein (TCTP) prolongs the survival of CD4+CD25high regulatory T cells (Tregs) by a transgenic approach. |
| 10 | 19362713 | In contrast, when only costimulatory signals were provided through CD28, Ly49A engagement did not block p38 MapK or Akt phosphorylation. |