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Gene Information
Gene symbol: CD86
Gene name: CD86 molecule
HGNC ID: 1705
Synonyms: B7.2, B7-2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADAM11 | 1 hits |
| 2 | CD28 | 1 hits |
| 3 | CD4 | 1 hits |
| 4 | CD40 | 1 hits |
| 5 | CLEC7A | 1 hits |
| 6 | CTLA4 | 1 hits |
| 7 | FOXP3 | 1 hits |
| 8 | GORASP1 | 1 hits |
| 9 | IL12A | 1 hits |
| 10 | IL1B | 1 hits |
| 11 | IL2 | 1 hits |
| 12 | IL2RA | 1 hits |
| 13 | INS | 1 hits |
| 14 | NFKB1 | 1 hits |
| 15 | RELB | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7532678 | Female NOD mice treated at the onset of insulitis (2-4 wk of age) with CTLA4Ig immunoglobulin (Ig) (a soluble CD28 antagonist) or a monoclonal antibody (mAb) specific for B7-2 (a CD28 ligand) did not develop diabetes. |
| 2 | 11927616 | In addition, we observed different effects with selective blockade of either B7-1 or B7-2 molecules; B7-1 appears to deliver a negative signal by engaging CTLA-4, while B7-2 engagement of CD28 upregulates T cell proliferation and cytokine secretion. |
| 3 | 15142525 | This splice variant of CTLA-4, named ligand-independent CTLA-4 (liCTLA-4), lacks exon2 including the MYPPPY motif essential for binding to the costimulatory ligands B7-1 and B7-2. |
| 4 | 15972645 | CTLA-4 binding to B7-1/B7-2 is believed to be crucial for its inhibitory signal both by competing for CD28 binding to the same ligands and aggregating CTLA-4 to deliver negative signals. |
| 5 | 15999808 | This splice variant of CTLA4, named ligand-independent CTLA4 (liCTLA4), lacks exon 2 including the MYPPPY motif essential for binding to the costimulatory ligands B7-1 and B7-2. liCTLA4 is expressed as a protein in primary T cells and strongly inhibits T cell responses by binding and dephosphorylating the TcRzeta chain. |
| 6 | 16626552 | Compared with NG and HM treated MDCs, the expression of maturation markers such as CD1a, HLA-DR, CD83, CD86 were significantly upregulated, allogeneic T cells proliferation as well as the cytokines secretions (IL-2, IL-12, IL-10 and IFN-gamma) significantly increased in HG treated MDCs. |
| 7 | 16886063 | However, it has been difficult to explore the biology of selective engagement of CTLA-4 in vivo because CTLA-4 shares its ligands, B7-1 and B7-2, with CD28. |
| 8 | 19120268 | The BMDCs from NOD mice displayed reduced mRNA expressions of NF-kappaB components, p65, p50, p52, and RelB, compared to NON mice: the proportions of each molecule relative to those of NON DCs were 53.9, 54.1, 54.0, and 37.0%, respectively, which were accompanied with lowered expressions of downstream immunomodulatory molecules, including IL-6, CD80, CD86, 4-1BB, and CD40. |
| 9 | 20185806 | CD11c(+) eATMPhis expressed a mixed M1/M2 profile, with some M1 transcripts upregulated (IL-12p40 and IL-1beta), others downregulated (iNOS, caspase-1, MCP-1, and CD86), and multiple M2 and matrix remodeling transcripts upregulated (arginase-1, IL-1Ra, MMP-12, ADAM8, VEGF, and Clec-7a). |
| 10 | 18828769 | Both IL-2 and CD28-CD80/CD86 signaling are critical for CD4(+)CD25(+)FOXP3(+) Treg survival in mice. |
| 11 | 20956025 | In contrast, incubation of iDCs with proinsulin partially suppressed CD86 co-stimulatory factor mediated DC activation, while incubation of iDCs with CTB-INS fusion protein completely suppressed iDC biosynthesis of both CD86 and CD83 costimulatory factors. |
| 12 | 22069288 | Bone marrow-derived dendritic cells displayed a different surface marker profile in the presence of 1,25(OH)(2) D(3) with decreased MHC II, CD86 and CD80 and increased CCR5, DEC205, F4/80 and CD40, as well as lower IL6 and IL12 expression upon LPS/IFN? stimulation. |