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Gene Information
Gene symbol: CDC42
Gene name: cell division cycle 42 (GTP binding protein, 25kDa)
HGNC ID: 1736
Synonyms: G25K, CDC42Hs
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | AKT1 | 1 hits |
| 3 | ARHGDIA | 1 hits |
| 4 | CD36 | 1 hits |
| 5 | IQGAP1 | 1 hits |
| 6 | PKN1 | 1 hits |
| 7 | RETN | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12938160 | The binding of IQGAP1 to its partners is regulated by calcium/calmodulin (Ca(++)/CaM) and the small molecular weight guanine nucleotide triphosphatases (GTPases), Cdc42, and Rac1. |
| 2 | 19596003 | The phosphorylation of Akt and the activations of Cdc42 and Rac1 were significantly increased by adiponectin. |
| 3 | 19596003 | Adiponectin increased the migration activity of EPCs, which was completely inhibited by a PI3-kinase inhibitor. siRNA of Cdc42 or Rac1 completely inhibited the adiponectin-induced migration, but siRNA of Akt had no effects, indicating that adiponectin promotes the migration activities of EPCs mainly through PI3-kinase/Cdc42/Rac1. |
| 4 | 19684036 | In addition, resistin activates RhoA, Rac-1, and Cdc42 in these cells as shown by affinity precipitation experiments. |
| 5 | 20028975 | Replenishment of RhoGDI to RNA interference-depleted cells normalized secretion, confirming the action of RhoGDI to be that of a negative regulator of Cdc42 activation. |
| 6 | 21545834 | PA also increased Cdc42 protein and its tyrosine nitration, thereby rearranging the cytoskeleton and facilitating CD36 translocation. |
| 7 | 21969371 | Analyses of human and mouse islet beta cell signaling revealed PAK1 activation to be 1) dependent upon Cdc42 abundance, 2) crucial for signaling downstream to activate ERK1/2, but 3) dispensable for cofilin phosphorylation. |