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Gene Information
Gene symbol: CDC73
Gene name: cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
HGNC ID: 16783
Synonyms: parafibromin
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACTN4 | 1 hits |
| 2 | MYC | 1 hits |
| 3 | PAF1 | 1 hits |
| 4 | PXMP3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18687124 | Parafibromin interacted with muscle alpha-actinins (actinin-2 and actinin-3), but not with non-muscle alpha-actinins (actinin-1 and actinin-4). |
| 2 | 18987311 | We show here that RNA interference with the expression of parafibromin or Paf1 stimulates cell proliferation and increases levels of the c-myc proto-oncogene product, a DNA-binding protein and established regulator of cell growth. |
| 3 | 18987311 | Knockdown of c-myc blocks the proliferative effect of RNA interference with parafibromin or Paf1 expression. |
| 4 | 18987311 | These experiments provide a previously uncharacterized mechanism for the anti-proliferative action of the parafibromin tumor suppressor protein resulting from PAF1 complex-mediated inhibition of the c-myc proto-oncogene. |