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Gene Information
Gene symbol: CDH5
Gene name: cadherin 5, type 2 (vascular endothelium)
HGNC ID: 1764
Synonyms: 7B4, CD144
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | C11orf2 | 1 hits |
| 2 | CDH17 | 1 hits |
| 3 | EDN1 | 1 hits |
| 4 | HMOX1 | 1 hits |
| 5 | IGF1 | 1 hits |
| 6 | PLAU | 1 hits |
| 7 | TGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17883332 | An adenoviral vector expressing human HO-1 was constructed using a VE-cadherin (VECAD) promotor fragment, and cell-specific expression of the recombinant adenovirus was examined using endothelial and vascular smooth muscle cells. |
| 2 | 18559877 | The increased retinal vascular permeability in diabetic rats was associated with a decrease in vascular endothelial (VE) -cadherin expression in retinal vessels. |
| 3 | 18559877 | Treatment of endothelial cells with specific matrix metalloproteinases or AGEs resulted in loss of VE-cadherin from the cell surface, which could be inhibited by A6. uPA/uPAR physically interacts with AGEs/receptor for advanced glycation end products on the cell surface and regulates its activity. uPA and its receptor uPAR play important roles in the alteration of the blood-retinal barrier through proteolytic degradation of VE-cadherin. |
| 4 | 19729486 | Confocal microscopy and real-time PCR showed that transforming growth factor (TGF)-beta1 induced de novo expression of alpha-SMA and loss of expression of VE-cadherin and CD31 in MMECs and primary cultures of renal endothelial cells in a time- and dose-dependent fashion. |
| 5 | 20497976 | Targeted ET-1 gene silencing by small interfering RNA in cultured human endothelial cells ameliorated high glucose-induced phenotypic transition and acquisition of a fibroblast marker through the inhibition of transforming growth factor-beta signaling activation and preservation of the endothelial cell-to-cell contact regulator VE-cadherin. |
| 6 | 21310918 | Ang-2 increased HREC monolayer permeability that was associated with a decrease in VE-cadherin and a change in monolayer morphology. |
| 7 | 21310918 | Increased Ang-2 alters VE-cadherin function, leading to increased vascular permeability. |
| 8 | 21549192 | Furthermore, IGF-1 reduces the level of intercellular adherence molecule VE-cadherin and increases monolayer permeability in TR-iBRB2 cells when measured by FITC-dextran leakage. |
| 9 | 21549192 | Similarly, K-CREB reverses IGF-1 down-regulation of VE-cadherin and up-regulation of fibronectin. |