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Gene Information
Gene symbol: CDK4
Gene name: cyclin-dependent kinase 4
HGNC ID: 1773
Synonyms: PSK-J3
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | ATF3 | 1 hits |
| 3 | CCK | 1 hits |
| 4 | CDC2 | 1 hits |
| 5 | CDK2 | 1 hits |
| 6 | CDKN1C | 1 hits |
| 7 | INS | 1 hits |
| 8 | NPHS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16428460 | While ATF3 failed to induce expressions of VEGF and VEGFR, it regulated those of CDK2, CDK4, p8, plasminogen activator inhibitor 1, integrin alpha1, subunit and matrix metalloprotease MMP13. |
| 2 | 18845673 | Analysis of cyclin and cdk mRNA and protein abundance revealed that CCK overexpression increased cyclin A, cyclin B, cyclin E, cdk1, and cdk2 with no change in cyclin D1, cyclin D2, cyclin D3, cdk4, or cdk6 in mouse and human islets. |
| 3 | 19343564 | In Reg3alpha-expressing cells, we detected 2.2- and 2.5-fold increased levels of cyclin D1 and CDK4, respectively, which paralleled a 1.8-fold increase in the rate of Akt phosphorylation. |
| 4 | 20668098 | Compared with podocytes transformed with a thermo-sensitive SV40 large T antigen mutant tsA58U19 (tsT podocytes), podocytes transformed with CDK4 (CDK4 podocytes) exhibited significantly higher expression of nephrin mRNA. |
| 5 | 15821902 | CDK4 is involved in the regulation of body weight, pancreatic beta-cell proliferation, insulin responsiveness, and diabetes pathogenesis. |
| 6 | 15821902 | CDK4 activity is inhibited by CDKN1C, which is regulated by insulin. |