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Gene Information
Gene symbol: CDK5
Gene name: cyclin-dependent kinase 5
HGNC ID: 1774
Synonyms: PSSALRE
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CDK5R1 | 1 hits |
| 2 | CDK5R2 | 1 hits |
| 3 | CDKAL1 | 1 hits |
| 4 | INS | 1 hits |
| 5 | MYC | 1 hits |
| 6 | PDX1 | 1 hits |
| 7 | SYN1 | 1 hits |
| 8 | TCF7L2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11443123 | In addition, Cdk5 phosphorylates munc-18 and synapsin I, two essential components of the exocytotic machinery. |
| 2 | 14976144 | Overactivity of CDK5 occurs by proteolytic cleavage and cellular mislocalization of its activator, p35. |
| 3 | 14976144 | Functional studies show that p35 stimulates the activity of the insulin promoter and that the stimulation requires CDK5 because stimulation is blocked by roscovitine, an inhibitor of CDK5 activity, a dominant negative form of CDK5, and small interfering RNAs against p35. |
| 4 | 15908038 | Cdk5 needs to associate with one of the regulatory proteins p35 or p39 to be an active enzyme. |
| 5 | 15908038 | Endogenous Cdk5 and p35 protein levels increased with cellular differentiation and preferentially distributed to soluble pools, whereas the level of p39 protein remained low and primarily was present in membrane and cytoskeletal fractions. |
| 6 | 16887799 | Inhibition of CDK5 prevented this decrease of insulin gene expression. |
| 7 | 16887799 | Analyses of nuclear and cytoplasmic PDX-1 protein levels revealed that CDK5 inhibition restores nuclear PDX-1, without affecting its cytoplasmic concentration, suggesting that CDK5 regulates the nuclear/cytoplasm partitioning of PDX-1. |
| 8 | 16887799 | Using a Myc-tagged PDX-1 construct, we showed that the translocation of PDX-1 from the nucleus to the cytoplasm during glucotoxic conditions was prevented when CDK5 was inhibited. |
| 9 | 17979810 | It has been widely accepted that aberrant Cdk5 activity induced by the conversion of p35 to p25 plays roles in the pathogenesis of neurodegenerative diseases. |
| 10 | 21151568 | Our results indicate that CDKAL1 controls first-phase insulin exocytosis in ? cells by facilitating ATP generation, K(ATP) channel responsiveness and the subsequent activity of Ca(2+) channels through pathways other than CDK5-mediated regulation. |
| 11 | 19718565 | Novel risk loci for type 2 diabetes, single nucleotide polymorphism (SNP) rs7756992 in cyclin-dependent kinase 5 (CDK5) regulatory subunit associated protein 1-like 1 (CDKAL1), rs290487 and rs11196218 in transcription factor 7-like 2 (TCF7L2), were recently identified. |
| 12 | 21611789 | The diabetogenic role of CDKAL1 variants is suggested to consist in lower insulin secretion probably due to the insufficient inhibition of the CDK5 activity. |
| 13 | 22028710 | Inhibition of CDK5 averts the decrease of insulin gene expression through the inhibition of nuclear translocation of PDX-1 which is a transcription factor for the insulin gene. |