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Gene Information
Gene symbol: CDKN1B
Gene name: cyclin-dependent kinase inhibitor 1B (p27, Kip1)
HGNC ID: 1785
Synonyms: KIP1, P27KIP1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | COL8A2 | 1 hits |
| 2 | DACH1 | 1 hits |
| 3 | DCN | 1 hits |
| 4 | EGF | 1 hits |
| 5 | EGFR | 1 hits |
| 6 | FOXM1 | 1 hits |
| 7 | GSK3B | 1 hits |
| 8 | PRKCA | 1 hits |
| 9 | PSMD9 | 1 hits |
| 10 | PTGS2 | 1 hits |
| 11 | SRA1 | 1 hits |
| 12 | TGFB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10432377 | High-glucose-induced activation of protein kinase C and stimulated TGF-beta expression appear to be essential for stimulated expression of p27Kip1. |
| 2 | 16556734 | The decline in beta-cell mass in Foxm1(Deltapanc) animals is due to a dramatic decrease in postnatal beta-cell replication and a corresponding increase in nuclear localization of the cyclin-dependent kinase inhibitor, p27(Kip1), a known target of FoxM1 inhibition. |
| 3 | 18096720 | Twenty-five millimolar glucose also increased the level of the cell cycle regulatory proteins (cyclin E/cyclin-dependent kinase [CDK] 2 and cyclin D1/CDK 4) and decreased p21(WAF1/Cip1) and p27(Kip1), which were blocked by the inhibition of the cPLA(2), COX-2, or PPARdelta pathways. |
| 4 | 19401424 | Col8a1(-)/Col8a2(-) mesangial cells revealed decreased proliferation, less phosphorylation of Erk1/2, and increased p27(Kip1) expression. |
| 5 | 20083846 | We discovered that streptozotocin-induced diabetes in Dcn(-/-) mice led to increased proteinuria associated with enhanced cyclin-dependent kinase inhibitor p27Kip1 in podocytes and tubular epithelial cells. |
| 6 | 18288891 | Preservation of beta-cell mass in Gsk-3beta+/- Irs2-/- mice was accompanied by suppressed p27(kip1) levels and increased Pdx1 levels. |
| 7 | 20869363 | In ?-cells, Dach1 bound to the promoter of the cell cycle inhibitor p27Kip1, which constrains ?-cell proliferation. |
| 8 | 21152033 | SRA promotes S-phase entry during mitotic clonal expansion, decreases expression of the cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1, and increases phosphorylation of Cdk1/Cdc2. |
| 9 | 19279131 | Alterations in proliferation were associated with changes in p27(kip1) expression. |
| 10 | 17270172 | Our results suggest that quiescence of small cells correlates with up-regulation of Cdk inhibitors p27(Kip1), p16(INK4a) and p21(CIP1), PTEN, Hep27 and Foxo1a and with down-regulation of c-Myc and the receptors for EGF, FGF2 and HGF. |
| 11 | 17270172 | The exit from quiescence correlates with activation of EGFR expression and down-regulation of p27(Kip1) and p16(INK4a). |
| 12 | 21753123 | Finally, T0901317 up-regulated the palmitic acid-induced expression of p27(KIP1), transforming growth factor beta 1, and SMAD3 proteins in INS-1 cells. |