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Gene Information
Gene symbol: CDKN2A
Gene name: cyclin-dependent kinase inhibitor 2A
HGNC ID: 1787
Synonyms: CDK4I, p16, INK4a, MTS1, CMM2, ARF, p19, p14, INK4, p16INK4a, p19Arf
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | APOB | 1 hits |
| 3 | CCND2 | 1 hits |
| 4 | CYP2D6 | 1 hits |
| 5 | EGF | 1 hits |
| 6 | EGFR | 1 hits |
| 7 | EZH2 | 1 hits |
| 8 | IL4 | 1 hits |
| 9 | MAPK1 | 1 hits |
| 10 | MAPK14 | 1 hits |
| 11 | PPARG | 1 hits |
| 12 | PPARGC1A | 1 hits |
| 13 | PSMD9 | 1 hits |
| 14 | PTHLH | 1 hits |
| 15 | SCD | 1 hits |
| 16 | TLR4 | 1 hits |
| 17 | UCP3 | 1 hits |
| 18 | ZMPSTE24 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11921186 | Notably, the tumors were highly diverse in histopathology and displayed extensive genetic/molecular alterations, including overexpression of ErbB2, c-Myc, p27, and Cyclin D1, and downregulation of p16 in the majority of tumors. |
| 2 | 19390090 | Conditional deletion of beta-cell Ezh2 in juvenile mice also reduced H3 trimethylation at the Ink4a/Arf locus, leading to precocious increases of p16(INK4a) and p19(Arf). |
| 3 | 20802255 | At the molecular level, adiponectin decreased high glucose-induced accumulation of intracellular reactive oxygen species and consequently suppressed activation of p38 MAP kinase (MAPK) and expression of the senescence marker p16(INK4A). |
| 4 | 19680556 | We re-sequenced all exons, intron-exon boundaries and selected conserved non-coding sequences of candidate genes involved in aging-related processes, including dietary restriction (PPARG, PPARGC1A, SIRT1, SIRT3, UCP2, UCP3), metabolism (IGF1R, APOB, SCD), autophagy (BECN1, FRAP1), stem cell activation (NOTCH1, DLL1), tumor suppression (TP53, CDKN2A, ING1), DNA methylation (TRDMT1, DNMT3A, DNMT3B) Progeria syndromes (LMNA, ZMPSTE24, KL) and stress response (CRYAB, HSPB2). |
| 5 | 17270172 | Our results suggest that quiescence of small cells correlates with up-regulation of Cdk inhibitors p27(Kip1), p16(INK4a) and p21(CIP1), PTEN, Hep27 and Foxo1a and with down-regulation of c-Myc and the receptors for EGF, FGF2 and HGF. |
| 6 | 17270172 | The exit from quiescence correlates with activation of EGFR expression and down-regulation of p27(Kip1) and p16(INK4a). |
| 7 | 21636855 | Transcriptome analysis revealed that p16(-/-) BM-derived macrophages (BMDMs) exhibit a phenotype resembling IL-4-induced macrophage polarization. |
| 8 | 21800111 | Analysis of islet G1/S cell cycle proteins revealed that chronic overabundance of PTHrP(1-139) in the beta cell significantly increased the cell cycle activator cyclin D2 and decreased levels of cyclin-dependent kinase 4 inhibitor (p16( Ink4a ) [Ink4a also known as Cdkn2a]), but acute treatment with PTHrP(1-36) did not. |
| 9 | 21787170 | The metabolism of berberine in MLM and HLM was decreased the most by a CYP2D inhibitor, and moderately by inhibitors of CYP1A and 3A. |
| 10 | 21968977 | Western blot analysis revealed that p16(INK4A) overproduction inhibits LPS- and palmitate-induced Toll-like receptor 4 (TLR4)-nuclear factor of ? light polypeptide gene enhancer in B cells (NF-?B) signalling. |