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Gene Information
Gene symbol: CFLAR
Gene name: CASP8 and FADD-like apoptosis regulator
HGNC ID: 1876
Synonyms: CASH, Casper, CLARP, FLAME, FLIP, I-FLICE, MRIT, c-FLIP
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CASP10 | 1 hits |
| 2 | CASP8 | 1 hits |
| 3 | FAS | 1 hits |
| 4 | IFNG | 1 hits |
| 5 | IL1B | 1 hits |
| 6 | NFKB1 | 1 hits |
| 7 | NOS2A | 1 hits |
| 8 | TNFRSF10B | 1 hits |
| 9 | TNFSF10 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11976344 | Caspase-8 and caspase-10 were also recruited to the DISC in TRAIL-resistant cells, but their further activation was inhibited by two antiapoptotic proteins termed cellular Fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein (c-FLIP) and phosphoprotein enriched in diabetes/phosphoprotein enriched in astrocytes-15kDa (PED/PEA-15). |
| 2 | 17003335 | Fas engagement can be switched from death signal to induction of proliferation when the caspase 8 inhibitor, FLICE-inhibitory protein (FLIP), is active. |
| 3 | 17003335 | Consistent with our in vitro results, IL-1beta knockout mice displayed glucose intolerance along with a decrease in islet Fas, FLIP, Pax4, and PDX-1 transcripts. |
| 4 | 19343319 | In addition to the upregulation of known pro-apoptotic genes, a number of anti-apoptotic genes including BIRC3, BCL2A1, TNFAIP3, CFLAR and TRAF1 were induced by cytokines through NF-kappaB. |
| 5 | 19432816 | In TRAIL-resistant cells, however, DR5-mediated DISC was modified by receptor-interacting protein (RIP), cellular FADD-like interleukin-1beta-converting enzyme inhibitory protein (c-FLIP) and phosphoprotein enriched in diabetes or in astrocyte-15 (PED/PEA-15). |
| 6 | 12031968 | Furthermore, cFLIP overexpression increased the basal and interleukin-1beta-mediated transcriptional activity of nuclear factor (NF)-kappaB, whereas it did not change cytokine-induced inducible nitric oxide synthase gene transcription and nitric oxide secretion. |
| 7 | 12031968 | The presence of cFLIP prevented the weak TNF-alpha-induced reduction in cellular insulin content and secretion; however, it did not prevent the decrease in glucose-stimulated insulin secretion induced by the combined cytokines, in agreement with our previous data demonstrating that interferon-gamma alone could induce these beta-cell dysfunctions. |
| 8 | 12031968 | Together, our data demonstrate that overexpression of cFLIP protects mouse beta-cells against TNF-alpha-induced caspase-8 activation and apoptosis and is correlated with enhanced NF-kappaB transcriptional activity, suggesting that cFLIP may have an impact on the outcome of death receptor-triggered responses by directing the intracellular signals from beta-cell death to beta-cell survival. |