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Gene Information
Gene symbol: CNTF
Gene name: ciliary neurotrophic factor
HGNC ID: 2169
Synonyms: HCNTF
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | AGRP | 1 hits |
| 3 | EPO | 1 hits |
| 4 | INS | 1 hits |
| 5 | LEP | 1 hits |
| 6 | MAPK1 | 1 hits |
| 7 | POMC | 1 hits |
| 8 | PTGS2 | 1 hits |
| 9 | RETN | 1 hits |
| 10 | SOCS2 | 1 hits |
| 11 | SOCS3 | 1 hits |
| 12 | STAT1 | 1 hits |
| 13 | STAT3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12424252 | In order to investigate the effects of CNTF on fat cells, we examined the expression of CNTF receptor complex proteins (LIFR, gp130, and CNTFRalpha) during adipocyte differentiation and the effects of CNTF on STAT, Akt, and MAPK activation. |
| 2 | 12424252 | Our studies clearly demonstrate that the expression of two of the three CNTF receptor complex components, CNTFRalpha and LIFR, decreases during adipocyte differentiation. |
| 3 | 12424252 | Moreover, we demonstrated that CNTF can activate STAT 3 in adipose tissue and skeletal muscle in vivo. |
| 4 | 12424252 | In summary, CNTF affects adipocyte gene expression, and the specific receptor for this cytokine is induced in rodent models of obesity/type II diabetes. |
| 5 | 15522996 | We also studied whether treatment with the weight-reducing and insulin-sensitizing compounds, MTII, an alpha-melanocyte-stimulating hormone analog, or CNTF(Ax15), a ciliary neurotrophic factor analog, alters resistin mRNA expression and/or circulating levels in lean and DIO C57BL/6J mice. |
| 6 | 18210031 | CNTF acts both centrally and peripherally, mimics the biological actions of leptin while overcoming "leptin resistance", remains effective even after termination of therapy if administered centrally, and appears to reduce inflammatory signaling cascades associated with lipid accumulation in liver and skeletal muscle. |
| 7 | 21484573 | CNTF is a gp130 ligand that has been found to act centrally and peripherally to promote weight loss and insulin sensitivity in both human and rodent models. |
| 8 | 11078456 | To comparatively assess the roles of CNTF and leptin in reversing the starvation-induced changes of hypothalamic neuropeptides and endocrine function and in inducing expression of hypothalamic inhibitors of leptin and CNTF signaling (suppressor of cytokine signaling 3 [SOCS-3]) and mediators of energy expenditure (cyclo-oxygenase 2 [COX-2]), we studied the effect of CNTF and leptin administered by intraperitoneal injections (1 microg/g twice daily) in C57Bl/6J mice fasted for 48 h. |
| 9 | 11078456 | Leptin administration decreased NPY and AgRP and increased POMC mRNA levels toward baseline, but CNTF administration in fasted mice had no effect of comparable significance. |
| 10 | 11078456 | Both leptin and CNTF administration in fasted mice resulted in an induction of SOCS-3 mRNA expression. |
| 11 | 11078456 | CNTF also induced hypothalamic SOCS-2 mRNA expression. |
| 12 | 11078456 | Finally, neither leptin nor CNTF administration in mice fasted for 48 h alters hypothalamic COX-2 expression. |
| 13 | 21622158 | The results showed that intravitreal EPO ameliorated the up-regulation of GFAP and vimentin in the diabetic retina evaluated by immunofluorescence and Western blotting; but up-regulated BDNF and CNTF expressions, quantified by real-time PCR and ELISA, in the 24-week diabetic rat retinas. |