Ignet

Gene Information

Gene symbol: COL4A4

Gene name: collagen, type IV, alpha 4

HGNC ID: 2206

Synonyms: CA44

Related Genes

#	Gene Symbol	Number of hits
1	ACE2	1 hits
2	AGRN	1 hits
3	AGT	1 hits
4	ALB	1 hits
5	CD44	1 hits
6	COL1A1	1 hits
7	CTGF	1 hits
8	FCGR1A	1 hits
9	INS	1 hits
10	MAPK1	1 hits
11	MAPK8	1 hits
12	NOS3	1 hits
13	PRKCB1	1 hits
14	SERPINE1	1 hits
15	SERPINF1	1 hits
16	STAT3	1 hits
17	TGFB1	1 hits
18	TIMP1	1 hits
19	TIMP2	1 hits
20	VEGFA	1 hits

Related Sentences

#	PMID	Sentence
1	2482599	While the enlarged mesangial matrix in diffuse glomerulosclerosis showed an increased staining reaction for the basement membrane components collagen IV and V, laminin and fibronectin, the staining pattern of the basement membrane associated heparan sulfate proteoglycan (HSPG) was markedly reduced.
2	7626693	Collagen IV decreased in serum of patients with increased albumin excretion (controls: mean = 255 micrograms/l, normoalbuminuric patients: mean = 56 micrograms/l, microalbuminuric patients: mean = 52 micrograms/l, and patients with overt albuminuria: mean = 70 micrograms/l; alpha < 0.01) and increased in urine (controls, normoalbuminuric and microalbuminuric patients: not detectable, patients with overt albuminuria: mean = 5 ng/12 h; apha < 0.001).
3	11967010	Both high glucose (HG) and angiotensin II (Ang II) causes glomerular mesangial cell (GMC) growth and increased synthesis of matrix proteins like collagen IV contributing to diabetic nephropathy.
4	11967010	We hypothesized that Ang II activation of the JAK/STAT pathway is altered by HG in GMC, and that this pathway might be linked to the Ang II-induced growth and overproduction of collagen IV in GMC in HG conditions.
5	16196291	It is concluded that calcium dobesilate can improve diabetic nephropathy by inhibiting the over- accumulation of collagen IV and calcium dobesilate may also contribute to diabetes by inhibiting the expression of TIMP1.
6	16380480	Similarly, diabetic rats intravitreally injected with the combined AS-oligos and examined after 2 months of diabetes showed significant reduction in retinal fibronectin, laminin, and collagen IV expression.
7	17003336	The integrin-dependent adhesion of fetal beta-cells to both collagen IV and vitronectin induces significant glucose-independent insulin secretion and a substantial reciprocal decline in insulin content.
8	17003336	Using real-time PCR, we demonstrate that adhesion of both fetal and adult beta-cells to collagen IV and vitronectin also results in the marked suppression of insulin gene transcription.
9	17506941	Fasting blood glucose, creatinine (Cr), blood urea nitrogen (BUN), urine protein, kidney index, anti-oxidase, advanced glycosylation end products (AGE), collagen IV and laminin, matrix metalloproteinases-2 (MMP-2) and the tissue inhibitor of metalloproteinase-2 (TIMP-2), connective tissue growth factor (CTGF), and transforming growth factor-beta1 (TGF-beta1) mRNA were measured by different methods.
10	17768702	Agrin expression was significantly altered in diabetic versus non-diabetic MHS animals, whereas collagen I was expressed only in diabetic MHS rats and collagen IV content did not change significantly between the two groups.
11	17728702	Collagen IV gene expression was completely normalized by TGF-beta neutralization; however, this was associated with plasminogen activator inhibitor-1 (PAI-1) overexpression and a modest reduction in collagen protein.
12	19862499	In diabetic mice, high-dose avosentan treatment significantly attenuated the glomerulosclerosis index, mesangial matrix accumulation, glomerular accumulation of the matrix proteins collagen IV, and renal expression of genes encoding connective tissue growth factor, vascular endothelial growth factor, transforming growth factor beta and nuclear factor kappaB (p65 subunit).
13	21106770	Moreover, C-peptide (300 nM) completely inhibited the glucose-induced increase of the collagen IV mRNA expression and protein concentration in mesangial cells cultured in 30 mM glucose medium.
14	19207983	The pattern of collagen IV expression was the same in both tissue groups and was not found to be up-regulated.
15	20844835	An experiment in cultured glomerular mesangial cells was performed to examine the effects of ACE2 on cellular proliferation, oxidative stress and collagen IV synthesis.
16	20844835	In comparison with the Ad-GFP group, the Ad-ACE2 group exhibited reduced systolic blood pressure, urinary albumin excretion, creatinine clearance, glomeruli sclerosis index and renal malondialdehyde level; downregulated transforming growth factor (TGF)-?1, vascular endothelial growth factor (VEGF) and collagen IV protein expression; and increased renal superoxide dismutase activity.
17	20844835	ACE2 transfection attenuated angiotensin (Ang) II-induced glomerular mesangial cell proliferation, oxidative stress and collagen IV protein synthesis.
18	11997313	Enhanced collagen IV expression by mesangial cells in response to vasoactive peptide hormone stimulation, e.g., endothelin-1, requires PKC-beta, -delta, -epsilon and -zeta.
19	16449352	We found that pretreatment with simvastatin significantly inhibited HG- and ANG II-induced collagen IV production, JAK2 activation, and phosphorylation of STAT1 and STAT3 in GMC.
20	21514434	Vorinostat treatment had no effect on albuminuria, glomerular collagen IV concentration, or mesangiolysis in diabetic mice genetically deficient in eNOS.
21	21439910	We found that oxLDL-IC markedly stimulated collagen IV expression in a concentration- and time-dependent fashion while oxLDL only had moderate effect.
22	21439910	We also found that oxLDL-IC stimulated collagen IV expression by engaging Fc gamma receptor (Fc?R) I and III, but not Fc?RII, and that p38 MAPK, JNK and PKC pathways were involved in collagen IV expression.
23	21439910	Furthermore, we found that oxLDL-IC stimulated Fc?RI expression, suggesting a positive feedback mechanism involved in oxLDL-IC-stimulated collagen IV expression.
24	21208996	NaHS did not change ROS generation, cell proliferation, TGF-?1 and collagen IV expression in the cells cultured with normal glucose.
25	21858384	The PEDF significantly inhibited the overexpression of transforming growth factor-beta 1, and extracellular matrix proteins (fibronectin and collagen IV) induced by the elevated glucose in HMCs.
26	21780924	In parallel cell cultures, fibronectin and collagen IV protein expression were determined using Western Blot analysis.
27	21780924	Western blot analysis showed increased fibronectin and collagen IV expression (152?�?24% of control, p?=?0.01; 146?�?16% of control, p?=?0.02, respectively) in cells grown in HG compared to those grown in N medium.