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Gene Information
Gene symbol: COX8A
Gene name: cytochrome c oxidase subunit VIIIA (ubiquitous)
HGNC ID: 2294
Synonyms: COX8-2, COX8L, VIII-L, COX, VIII
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AVP | 1 hits |
| 2 | IL1B | 1 hits |
| 3 | INS | 1 hits |
| 4 | MMP2 | 1 hits |
| 5 | MMP9 | 1 hits |
| 6 | PTGIS | 1 hits |
| 7 | PTGS1 | 1 hits |
| 8 | PTGS2 | 1 hits |
| 9 | REN | 1 hits |
| 10 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 6093608 | The present experiments were done to investigate whether this increase in COX activity could be eliminated by administration of exogenous arginine vasopressin (AVP). |
| 2 | 7505613 | IL-1 beta also stimulates the production of the cyclooxygenase (COX) product prostaglandin E2 (PGE2). |
| 3 | 7505613 | In this study we have examined the effects of IL-1 beta on both inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (iCOX) expression, and the direct effects of nitric oxide on the activity of COX. |
| 4 | 9465095 | The enzyme cyclooxygenase (COX)-1 is constitutive whereas COX-2 is regulated in virtually all tissues. |
| 5 | 12808136 | In addition, muscle mitochondrial protein synthesis, and COX and citrate synthase enzyme activities were increased by insulin (P < 0.05). |
| 6 | 15983217 | Immunoblots showed a 73% reduction in PGI2 synthase (PGIS) expression in ZDF vessels compared with lean vessels, and there was no change in cyclooxygenase (COX) and BK channel expressions. |
| 7 | 16966336 | Taken together, these observations reveal that PPARdelta induces COX-2 expression in human cholangiocarcinoma cells and that the COX-2-derived PGE2 further activates PPARdelta through phosphorylation of cPLA2alpha. |
| 8 | 19826189 | The COX inhibitor, indomethacin, decreased the gastric emptying which was induced or reversed by insulin in normal and DM rats, respectively. |
| 9 | 20213226 | In the present study, we have targeted MMP-2 and MMP-9 overactivation in diabetic neuropathy using a known MMP-2 and MMP-9 inhibitor, minocycline, with a non-selective COX inhibitor, aspirin. |
| 10 | 20213226 | The results of the present study suggest that MMP-2 and MMP-9 inhibition in the presence of COX inhibitor prevents the development of experimental diabetic neuropathy in rats and can be a potential approach for the treatment. |
| 11 | 20840078 | Experiments using specific COX and LOX (lipoxygenase) inhibitors demonstrated the importance of COX-1 activity for acute (20 min) stimulation of insulin secretion, suggesting that AA metabolites may be responsible for the insulinotropic effects. |
| 12 | 21437112 | Curcumin has been reviewed for its multiple molecular action on inhibiting tumor angiogenesis via its mechanisms of cyclooxygenase (COX)-2, and vascular endothelial growth factor (VEGF) inhibition. |
| 13 | 11053041 | Renin activity, afferent arteriolar granularity, and renin mRNA were determined in wild-type mice and in COX-2-knockout mice on control and low-NaCl diets. |
| 14 | 16954340 | In the current experiments, we determined the response of plasma renin concentration (PRC) to acute intraperitoneal administration of furosemide (40 mg/kg), hydralazine (2 mg/kg), isoproterenol (10 mg/kg), candesartan (50 microg), or quinaprilate (50 microg) in conscious wild-type (WT) and cyclooxygenase (COX)-2-/- mice on three different genetic backgrounds (mixed, C57BL/6, 129J). |
| 15 | 21219209 | Results of present study suggest that MMP-2 and MMP-9 inhibition in presence of COX inhibitor prevents the development of experimental diabetic nephropathy in rats and can be a potential approach for the treatment. |
| 16 | 20407607 | We hypothesized that minocycline induced MMP-2 and MMP-9 inhibition can be enhanced by aspirin, a non-selective COX and tPA inhibitor and this combination can reduce progression of diabetic retinopathy. |
| 17 | 20407607 | Results of the present study suggest that MMP-2 and MMP-9 inhibition in presence of COX inhibitor prevents the development of experimental diabetic retinopathy in rats and can be a potential approach for the treatment. |
| 18 | 21737546 | In vivo, podocyte pro(renin) receptor expression increased in diabetic COX-2-transgenic mice, and treatment with a COX-2 inhibitor abrogated the upregulation of (pro)renin receptor and reduced albuminuria, foot-process effacement, and mesangial matrix expansion. |