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Gene Information
Gene symbol: CPE
Gene name: carboxypeptidase E
HGNC ID: 2303
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CBX4 | 1 hits |
| 2 | CPD | 1 hits |
| 3 | GAPDH | 1 hits |
| 4 | INS | 1 hits |
| 5 | MARCH8 | 1 hits |
| 6 | MIRN197 | 1 hits |
| 7 | POMC | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7663508 | We now demonstrate a defect in proinsulin processing associated with the virtual absence of CPE activity in extracts of fat/fat pancreatic islets and pituitaries. |
| 2 | 15618358 | We conclude that lack of CPE in islet beta-cells results in a marked decrease in processing of proIAPP at its NH(2) (but not COOH) terminus that is associated with attenuated levels of PC2 and (pro)7B2 and a great reduction in formation of mature amidated IAPP. |
| 3 | 19035278 | GAPDH, hnRNP D and hnRNP A/B bind specifically to the p53 CPEs and could potentially be involved in the post-transcriptional regulation of p53. |
| 4 | 19767734 | We show that FoxO1 ablation in pro-opiomelanocortin (Pomc)-expressing neurons in mice (here called Pomc-Foxo1(-/-) mice) increases Carboxypeptidase E (Cpe) expression, resulting in selective increases of alpha-melanocyte-stimulating hormone (alpha-Msh) and carboxy-cleaved beta-endorphin, the products of Cpe-dependent processing of Pomc. |
| 5 | 21628999 | Previously, we demonstrated that lipotoxicity led to the degradation of CPE, but did not affect its related enzyme, carboxypeptidase D (CPD). |
| 6 | 21628999 | In this study, we found that CPD was significantly up-regulated by elevated glucose, while CPE was not. |
| 7 | 21628999 | Glucose and insulin did not affect CPD or CPE expression in an ?-cell line. |
| 8 | 21628999 | Furthermore, insulin treatment altered the CPD sub-cellular localization, which was distinct from CPE. |
| 9 | 21628999 | In addition, while our previous study demonstrated that even modest reduction of CPE was sufficient to induce ?-cell apoptosis, CPD knockdown did not affect cell viability. |
| 10 | 21998738 | Specifically, miR-30b* was downregulated by the three treatments, and treatment with GSPE or CPE upregulated miR-1224-3p, miR-197 and miR-532-3p. |