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Gene Information
Gene symbol: CREM
Gene name: cAMP responsive element modulator
HGNC ID: 2352
Synonyms: hCREM-2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BRD2 | 1 hits |
| 2 | CREB1 | 1 hits |
| 3 | GNRH1 | 1 hits |
| 4 | INS | 1 hits |
| 5 | RAB27A | 1 hits |
| 6 | RAB3A | 1 hits |
| 7 | RPH3AL | 1 hits |
| 8 | TCF7L2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 14534319 | Taken together, these data suggest that up-regulation of CREM repressors by either FFA or high glucose exacerbates beta-cell failure in type 2 diabetes by suppressing insulin gene transcription. |
| 2 | 16498408 | ICER overexpression diminished the level of Granuphilin, Noc2, Rab3a and Rab27a by binding to cAMP responsive elements located in the promoters of these genes and inhibited exocytosis of beta-cells in response to secretagogues. |
| 3 | 16498408 | We propose that induction of inappropriate ICER levels lead to defects in the secretory process of pancreatic beta-cells possibly contributing, in conjunction with other known deleterious effects of hyperglycemia, to defective insulin release in type 2 diabetes. |
| 4 | 16772326 | Correspondingly, SREBP-1c DN largely corrected decreases in the expression of the transcription factors Pdx-1 and MafA but did not affect the abnormalities in Pax6, Arx, hepatic nuclear factor-1alpha (HNF1alpha), HNF3beta/Forkhead box-a2 (Foxa2), inducible cyclic AMP early repressor (ICER), or transcription factor 7-like 2 (TCF7L2) expression observed in ZDF islets. |
| 5 | 20008557 | We hypothesized that high GnRH pulse frequencies might stimulate a transcriptional repressor(s) to attenuate the action of CRE binding protein (CREB) and show that inducible cAMP early repressor (ICER) fulfills such a role. |
| 6 | 20008557 | ICER was not detected under basal conditions, but pulsatile GnRH stimulated ICER to a greater extent at high than at low pulse frequencies. |
| 7 | 20008557 | ICER binds to the FSH beta CRE site to reduce CREB occupation and abrogates both maximal GnRH stimulation and GnRH pulse frequency-dependent effects on FSH beta transcription. |
| 8 | 20008557 | These data suggest that ICER production antagonizes the stimulatory action of CREB to attenuate FSH beta transcription at high GnRH pulse frequencies, thereby playing a critical role in regulating cyclic reproductive function. |
| 9 | 21998402 | CONCLUSIONS Impaired expression of ICER contributes to elevation in CREB target genes and, therefore, to the development of insulin resistance in obesity. |