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Gene Information
Gene symbol: CX3CL1
Gene name: chemokine (C-X3-C motif) ligand 1
HGNC ID: 10647
Synonyms: NTN, C3Xkine, ABCD-3, CXC3C, CXC3, fractalkine, neurotactin
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCR1 | 1 hits |
| 2 | CCR7 | 1 hits |
| 3 | CD4 | 1 hits |
| 4 | CX3CR1 | 1 hits |
| 5 | CXCL12 | 1 hits |
| 6 | CXCR4 | 1 hits |
| 7 | CXCR6 | 1 hits |
| 8 | FOS | 1 hits |
| 9 | MAPK1 | 1 hits |
| 10 | NFKB1 | 1 hits |
| 11 | NOX5 | 1 hits |
| 12 | RETN | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21873805 | On multiple regression, only CD4(+)CX3CR1(+) T cells and the presence of diabetes continued to show an association with IMT (p < 0.0001 and 0.0029 respectively).Conclusions: CKD subjects showed an increase in CD4(+)CX3CR1(+) T cell population, plasma fractalkine and IMT; the association of CD4(+)CX3CR1(+) T cells and plasma fractalkine with CCA-IMT indicates that the fractalkine-CX3CR1 pathway may be important in the development and/or progression of atherosclerosis in CKD. |
| 2 | 11264153 | Consistent with this, functional analysis of peripheral blood mononuclear cells showed that CX3CR1 I249 heterozygosity was associated with a significant decrease in the number of fractalkine binding sites per cell. |
| 3 | 15784733 | A minority of BM-MSCs (2% to 25%) expressed a restricted set of chemokine receptors (CXC receptor 4 [CXCR4], CX3C receptor 1 [CX3CR1], CXCR6, CC chemokine receptor 1 [CCR1], CCR7) and, accordingly, showed appreciable chemotactic migration in response to the chemokines CXC ligand 12 (CXCL12), CX3CL1, CXCL16, CC chemokine ligand 3 (CCL3), and CCL19. |
| 4 | 19132243 | In conclusion, HG upregulates the expression of fractalkine and MCP-1 in SMC leading to increased monocyte-SMC adhesive interactions by a mechanism involving activation of MAPK, activator protein-1 (AP-1) and NF-kappaB. |
| 5 | 20034466 | The results showed that in HEC (i) resistin increased P-selectin expression; (ii) HG up-regulated Fk expression; (iii) P-selectin and fractalkine were functional increasing monocyte adhesion to activated cells. |
| 6 | 20034466 | Co-stimulation with resistin and HG increased P-selectin and fractalkine mRNA and protein and induced monocyte adhesion, generated an increase in NADPH oxidase activity and of the intracellular reactive oxygen species and activated the NF-kB and AP-1 transcription factors at similar values as those of each activator. |
| 7 | 21525510 | A putative functional nonsynonymous single nucleotide polymorphism (rs3732378) in CX3CR1 was associated with adipose and metabolic traits, and plasma CX3CL1 levels were increased in patients with type 2 diabetes vs. nondiabetics (0.506 ± 0.262 vs. 0.422 ± 0.210 ng/mL, P < 0.0001). |