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Gene Information
Gene symbol: CXCR4
Gene name: chemokine (C-X-C motif) receptor 4
HGNC ID: 2561
Synonyms: LESTR, NPY3R, HM89, NPYY3R, D2S201E, fusin, HSY3RR, NPYR, CD184
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | BCL2 | 1 hits |
| 3 | CCL19 | 1 hits |
| 4 | CCL3 | 1 hits |
| 5 | CX3CL1 | 1 hits |
| 6 | CXCL12 | 1 hits |
| 7 | CXCL16 | 1 hits |
| 8 | NOS2A | 1 hits |
| 9 | PIK3CA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12383202 | The chemokine stromal-cell derived factor-1 (SDF-1) controls maturation, trafficking, and homing of certain subsets, lymphoid cells including immunogenic B and T cells, as a ligand of the CXCR4 chemokine receptor. |
| 2 | 15784733 | A minority of BM-MSCs (2% to 25%) expressed a restricted set of chemokine receptors (CXC receptor 4 [CXCR4], CX3C receptor 1 [CX3CR1], CXCR6, CC chemokine receptor 1 [CCR1], CCR7) and, accordingly, showed appreciable chemotactic migration in response to the chemokines CXC ligand 12 (CXCL12), CX3CL1, CXCL16, CC chemokine ligand 3 (CCL3), and CCL19. |
| 3 | 19142013 | These effects were mediated by increased expression of the chemokine receptor CXCR4 and were dependent on nitric oxide synthase activity. |
| 4 | 19476565 | Recent observation suggested that the CXCR4, a G-protein-coupled receptor with a unique ligand, CXCL12, might be involved in the pathogenesis for type 1 diabetes. |
| 5 | 20586815 | Exposure of primary VSMCs to high glucose (25 mM) led to the up-regulated expression of SDF-1? and CXCR4, activated PI-3K/Akt signalling, and consequently promoted the proliferation and chemotaxis of VSMCs. |
| 6 | 21567300 | Here we propose that beta cell injury induces SDF-1 production, and the SDF-1/chemokine (C-X-C motif) receptor 4 (CXCR4) interaction auto-activates Sdf1 expression, resulting in the autocrine production of SDF-1 by beta cells and the paracrine activation of glucagon-like peptide-1 (GLP-1) production by alpha cells. |
| 7 | 17878289 | In MIN6 beta-cells, a CXCR4 antagonist (AMD3100) induces apoptosis, increases reactive oxygen species, decreases expression levels of the anti-apoptotic protein Bcl-2, and reduces phosphorylation of the proapoptotic protein Bad. |