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Gene Information
Gene symbol: CYP17A1
Gene name: cytochrome P450, family 17, subfamily A, polypeptide 1
HGNC ID: 2593
Synonyms: P450C17, CPT7, S17AH
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CYP1A1 | 1 hits |
| 2 | CYP21A2 | 1 hits |
| 3 | CYP2B6 | 1 hits |
| 4 | ESR2 | 1 hits |
| 5 | PDHB | 1 hits |
| 6 | STAR | 1 hits |
| 7 | TBXAS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 1828239 | To test this hypothesis, we selected patients with polycystic ovary syndrome (PCO) and hypertestosteronemia and a group of individuals with adrenal hyperplasia (AH) and elevated DHEA and studied their 1) insulin and glucose responses to a 75-g oral glucose tolerance test, 2) insulin resistance by hypoglycemic responses to a standard dose of intravenous (IV) insulin, and 3) insulin binding and pyruvate dehydrogenase (PDH) responsiveness to insulin in phytohemagglutinin (PHA)-activated T lymphocytes. |
| 2 | 11170094 | PE due to virilizing-type adrenal hyperplasia, caused by common mutations in the genes encoding for the adrenal enzymes 21-hydroxylase and 11-hydroxylase, was ruled out. |
| 3 | 18704836 | The down-regulation of P450scc and P450c17 and the up-regulation of 3beta-HSD and aromatase during the differentiation of TGC from UTC in parallel with the up-regulation of ER beta and estrogen sulfotransferase in maturing TGC suggests a function of placental estrogens primarily as autoor intracrine regulators during this process and assigns to conjugated placental estrogens a role as inactivated by-products of TGC differentiation intended for excretion. |
| 4 | 21164259 | P450scc deficiency is the differential diagnosis of congenital lipoid adrenal hyperplasia caused by mutations in the steroidogenic acute regulatory protein, however, in contrast to the latter, these patients do not have adrenal hyperplasia but small adrenals and gonads. |
| 5 | 20410220 | Like all other microsomal cytochrome P450 (CYP) enzymes, CYP17A1 requires electron transfer from P450 oxidoreductase (POR). |