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Gene Information
Gene symbol: CYP2D6
Gene name: cytochrome P450, family 2, subfamily D, polypeptide 6
HGNC ID: 2625
Synonyms: CPD6, P450-DB1, CYP2D, P450C2D
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CDKN2A | 1 hits |
| 2 | CYP1A1 | 1 hits |
| 3 | CYP1A2 | 1 hits |
| 4 | CYP2B6 | 1 hits |
| 5 | CYP2C19 | 1 hits |
| 6 | CYP2C9 | 1 hits |
| 7 | TBXAS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20878594 | Evidence of cytochrome P450 (CYP)2D6 inhibition in clinical trials highlighted a concern for pharmacokinetic interaction with other drugs that are CYP2D6 substrates, as confirmed by a rise in the pharmacokinetic parameters of desipramine with concomitant administration of mirabegron. |
| 2 | 21276781 | While none of the OS components showed significant inhibition on CYP2C9, eupatorin strongly and uncompetitively inhibited CYP2D6 activity with a K(i) value of 10.2?M. |
| 3 | 21787170 | CYP2D6 was the primary recombinant human CYP producing these metabolites, followed by CYP1A2, 3A4, 2E1 and CYP2C19. |
| 4 | 21787170 | The metabolism of berberine in MLM and HLM was decreased the most by a CYP2D inhibitor, and moderately by inhibitors of CYP1A and 3A. |