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Gene Information
Gene symbol: CYP3A4
Gene name: cytochrome P450, family 3, subfamily A, polypeptide 4
HGNC ID: 2637
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CYP1A1 | 1 hits |
| 2 | CYP2B6 | 1 hits |
| 3 | CYP2C19 | 1 hits |
| 4 | NR1I2 | 1 hits |
| 5 | SLC35A2 | 1 hits |
| 6 | TBXAS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21920351 | We show that metformin dramatically suppresses PXR-mediated expression of CYP3A4 in hepatocytes. |
| 2 | 12931254 | According to the results of pharmacokinetic studies, pitavastatin showed favorable and promising safety profile; it was only slightly metabolized by the cytochrome P450 (CYP) system, its lactone form had no inhibitory effects on the CYP3A4-mediated metabolism of concomitantly administered drugs; P-glycoprotein-mediated transport did not play a major role in its disposition, and pitavastatin did not inhibit P-glycoprotein activity. |
| 3 | 15069169 | Amiodarone is a potent inhibitor of several different CYP isoenzymes, including CYP3A4. |
| 4 | 20437462 | GLB depletion and metabolite formation in human liver microsomes were most significantly inhibited by the CYP3A inhibitor ketoconazole compared with the inhibitors of other CYP isoforms. |
| 5 | 17591676 | Induction of CYP3A4 in human hepatocytes was consistent with studies in rats, but induction of CYP2Cs was unexpected. |
| 6 | 22101373 | Of interest, integrase inhibitors (INIs) - novel, potent anti-HIV drugs - are mainly metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1 and do not induce or inhibit CYP3A4. |