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Gene Information
Gene symbol: CYP7A1
Gene name: cytochrome P450, family 7, subfamily A, polypeptide 1
HGNC ID: 2651
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FOXO1 | 1 hits |
| 2 | INS | 1 hits |
| 3 | PPARGC1A | 1 hits |
| 4 | SOAT1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 1598076 | Hypercholesterolemia was associated with a defect of lipoprotein receptor activity and with elevated HMG-CoA reductase and cholesterol 7 alpha - hydroxylase; conversely ACAT activity was lower in Yoshida as compared to Brown Norway rats. |
| 2 | 14522988 | Furthermore, we show that PGC-1alpha activates the CYP7A1 promoter directly in transient transfection assays in cultured cells. |
| 3 | 14522988 | Thus, PGC-1alpha is a key activator of CYP7A1 and bile acid biosynthesis and is likely responsible for the fasting and diabetes dependent induction of CYP7A1. |
| 4 | 16885156 | The insulin-regulated forkhead box O1 (FoxO1) and steroid regulatory element-binding protein-1c (SREBP-1c) strongly inhibited hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor gamma coactivator-1alpha trans-activation of the CYP7A1 gene. |
| 5 | 16885156 | FoxO1 binds to an insulin response element in the rat CYP7A1 promoter, which is not present in the human CYP7A1 gene. |
| 6 | 16885156 | We conclude that insulin has dual effects on human CYP7A1 gene transcription; physiological concentrations of insulin rapidly inhibit FoxO1 activity leading to stimulation of the human CYP7A1 gene, whereas prolonged insulin treatment induces SREBP-1c, which inhibits human CYP7A1 gene transcription. |
| 7 | 19237543 | Consistent with recently reported results, we show CYP7A1 is a direct target of FoxO1. |