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Gene Information

Gene symbol: DCN

Gene name: decorin

HGNC ID: 2705

Synonyms: DSPG2, SLRR1B

Related Genes

#	Gene Symbol	Number of hits
1	ACE	1 hits
2	CDKN1B	1 hits
3	F2	1 hits
4	GRHL1	1 hits
5	TGFB1	1 hits

Related Sentences

#	PMID	Sentence
1	7850412	Thus, decorin offers hope as a treatment for progressive kidney diseases caused by the overproduction of TGF-beta.
2	19397838	In response to high glucose, several of these transcription factors regulate the gene encoding the profibrotic cytokine transforming growth factor beta, as well as genes for a range of other proteins implicated in inflammation and extracellular matrix turnover, including thrombospondin 1, the chemokine CCL2, osteopontin, fibronectin, decorin, plasminogen activator inhibitor 1 and aldose reductase.
3	20083846	We discovered that streptozotocin-induced diabetes in Dcn(-/-) mice led to increased proteinuria associated with enhanced cyclin-dependent kinase inhibitor p27Kip1 in podocytes and tubular epithelial cells.
4	20571025	Thrombin stimulated elongation of GAG chains and increased proteoglycan core protein expression and these responses were blocked by the TbetaRI antagonist, SB431542 and TbetaRI siRNA knockdown, as well as several protease-activated receptor (PAR)-1 antagonists.
5	20502052	The renal protective effect of decorin in diabetic rats is at least partly due to the downregulation of the TGF-beta(1)/Smad signaling pathway.
6	16380460	In diabetic mgR/+ and mgR/mgR, but not in wild-type mice, an induction of glomerular decorin expression was observed.
7	18348167	By affinity coelectrophoresis (ACE), we found reduced affinities of heparin and KSPGs for glycated but not normal collagen, whereas the dermatan sulfate (DS)PGs decorin and biglycan bound similarly to both, and that the affinity of heparin for normal collagen decreased with increasing pH.