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Gene Information

Gene symbol: DGKB

Gene name: diacylglycerol kinase, beta 90kDa

HGNC ID: 2850

Synonyms: KIAA0718, DGK, DGK-BETA

Related Genes

#	Gene Symbol	Number of hits
1	CAT	1 hits
2	DGKQ	1 hits
3	EGF	1 hits
4	INS	1 hits
5	PDGFA	1 hits
6	PPARG	1 hits
7	PRKCA	1 hits

Related Sentences

#	PMID	Sentence
1	11415460	PDGF markedly increased the DGK activity of cultured cells.
2	11415460	Epidermal growth factor and alpha-thrombin stimulated total DGK activity similarly to PDGF.
3	15117825	We report here that PPARgamma agonists, thiazolidinedione class drugs (TZDs), or 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) were capable of activating diacylglycerol (DAG) kinase (DGK), resulting in attenuation of DAG levels and inhibition of protein kinase C (PKC) activation.
4	15117825	These findings thus demonstrate a novel molecular action of PPARgamma agonists to suppress the DAG-PKC signaling pathway via upregulation of an endogenous attenuator, DGK.
5	21103350	SNPs from DGKB, MADD and SLC30A8 were associated with fasting glucose while PROX1 rs340874 was significantly associated with OGTT 2-h glucose (p?=?0.0392?0.0014, adjusted for age, gender and BMI), the glucose-raising allele also showed association to lower insulin secretion.
6	20185807	Abnormalities in early insulin secretion were suggested in glucose-raising allele carriers at MTNR1B, GCK, FADS1, DGKB, and PROX1 (lower insulinogenic index; no association with proinsulin or insulin sensitivity).
7	21725595	We previously reported that d-?-tocopherol, well known as an antioxidant, enhances diacylglycerol kinase (DGK) activity, leading to the reduction of excess DAG accumulation and PKC activation in the glomeruli of streptozotocin-induced diabetic rats.
8	21725595	The addition of antioxidative enzyme catalase to the cells reversed the H2O2-mediated down-regulation of DGK activity.