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Gene Information
Gene symbol: DKK1
Gene name: dickkopf 1 homolog (Xenopus laevis)
HGNC ID: 2891
Synonyms: SK, DKK-1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | ALPP | 1 hits |
| 3 | CTGF | 1 hits |
| 4 | ECT2 | 1 hits |
| 5 | IDDM2 | 1 hits |
| 6 | KRT9 | 1 hits |
| 7 | NR1I2 | 1 hits |
| 8 | PRKCA | 1 hits |
| 9 | TGFB1 | 1 hits |
| 10 | WNT1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17982348 | Recent progress in understanding the pathophysiology of bone metastases has pointed to several novel pathways: transforming growth factor beta; receptor activator of nuclear factor beta ligand and osteoprotegerin; and Wnt signaling pathways and associated factors such as dickkopf-1 and endothelin-1. |
| 2 | 19675559 | Furthermore, DKK1 induces the expression of keratin 9 and alpha-Kelch-like ECT2-interacting protein (alphaKLEIP) but downregulates the expression of beta-catenin, glycogen synthase kinase 3beta, protein kinase C, and proteinase-activated receptor-2 (PAR-2) in keratinocytes. |
| 3 | 20299474 | Dickkopf-1, a specific Wnt antagonist, also attenuated the high-glucose-induced CTGF overexpression, indicating a role of Wnt signaling in CTGF overexpression in diabetes. |
| 4 | 17932314 | ALP induction was inhibited by Dkk1, an antagonist of paracrine Wnt actions. |
| 5 | 21344486 | While WNT5A, FZD5, and DKK1 were highly expressed in PC3 cells, WNT1 and SFRP1 mRNA levels were higher in DU145 cells. |
| 6 | 21567076 | These results suggest that insulin-deficiency in IDDM decreases osteoblastogenesis associated with inhibition of Wnt signaling through the increased expression of Sost and Dkk1 and the inhibition of Akt activation. |