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Gene Information

Gene symbol: DPP8

Gene name: dipeptidyl-peptidase 8

HGNC ID: 16490

Synonyms: DP8, DPRP1, MSTP141, FLJ14920, FLJ20283, MGC26191

Related Genes

#	Gene Symbol	Number of hits
1	DPP4	1 hits
2	DPP9	1 hits
3	FAP	1 hits

Related Sentences

#	PMID	Sentence
1	18398600	In contrast, ASP8497 did not potently inhibit human DPP8 or DPP9 activity (IC(50)=1,700 nM and 100 nM, respectively) and exhibited selectivity against several proteases, including proline-specific proteases (IC(50)>10 microM).
2	18422675	At these high doses, the toxicities of a selective DPP-8/DPP-9 inhibitor that were reported previously (100% mortality in mice, alopecia, thrombocytopenia, reticulocytopenia, enlarged lymph nodes, splenomegaly and 20% mortality in rats) were not observed.
3	18422675	Thus, a mechanism other than DPP-8/DPP-9 inhibition likely underlies the toxicity previously reported to be associated with a selective DPP-8/DPP-9 inhibitor.
4	19837468	Recent data suggest that the early DPP4-specific inhibitors might also bind DPP8 and DPP9, thus exerting their effects through non-specific binding.
5	21510839	Because inhibition of DPP8 and/or DPP9 has been shown to cause severe toxicity in preclinical species, high selectivity is an important criterion in selecting DPP-IV inhibitors for clinical development.