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Gene Information
Gene symbol: DPP9
Gene name: dipeptidyl-peptidase 9
HGNC ID: 18648
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | DPP8 | 1 hits |
| 2 | FAP | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18398600 | In contrast, ASP8497 did not potently inhibit human DPP8 or DPP9 activity (IC(50)=1,700 nM and 100 nM, respectively) and exhibited selectivity against several proteases, including proline-specific proteases (IC(50)>10 microM). |
| 2 | 18422675 | At these high doses, the toxicities of a selective DPP-8/DPP-9 inhibitor that were reported previously (100% mortality in mice, alopecia, thrombocytopenia, reticulocytopenia, enlarged lymph nodes, splenomegaly and 20% mortality in rats) were not observed. |
| 3 | 18422675 | Thus, a mechanism other than DPP-8/DPP-9 inhibition likely underlies the toxicity previously reported to be associated with a selective DPP-8/DPP-9 inhibitor. |
| 4 | 21510839 | Because inhibition of DPP8 and/or DPP9 has been shown to cause severe toxicity in preclinical species, high selectivity is an important criterion in selecting DPP-IV inhibitors for clinical development. |