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Gene Information
Gene symbol: DUSP1
Gene name: dual specificity phosphatase 1
HGNC ID: 3064
Synonyms: HVH1, CL100, MKP-1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | MAPK1 | 1 hits |
| 3 | MAPK14 | 1 hits |
| 4 | MAPK8 | 1 hits |
| 5 | PDGFA | 1 hits |
| 6 | PPP1R3C | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17401436 | Expression of mitogen-activated protein phosphatase-1 (MKP-1), one of the phosphatases involved in inactivation of mitogen-activated protein kinase signaling, was increased in all diabetic groups, irrespective of metabolic control. |
| 2 | 17401436 | In summary, renal cortical p38 activity was increased in diabetic rats at early and advanced stages of nephropathy, as compared with non-diabetic animals, and attenuated by improved metabolic control. p38 activation in diabetes is likely to occur via multiple pathways and cannot be explained by downregulation of MKP-1. |
| 3 | 16814733 | We reconciled these results by demonstrating that in mkp-1(-/-) mice, JNK activity was increased in the nucleus, but not the cytosol. |
| 4 | 21562305 | The transient induction of MAP kinase phosphatase-1 (MKP-1), which mediates ERK dephosphorylation at the onset of myogenesis, was lost in ERR?-/- myocytes and in XCT790-treated C2C12. |
| 5 | 12176727 | Insulin inhibition of MAPK was accompanied by a rapid induction of MAPK phosphatase (MKP-1), which inactivates MAPKs by dephosphorylation. |
| 6 | 12176727 | Pretreatment with inhibitors of the nitric oxide (NO)/cGMP pathway, blocked insulin-induced MKP-1 expression and restored PDGF-stimulated MAPK activation and migration. |
| 7 | 12176727 | In contrast, adenoviral infection of VSMCs with MKP-1 or cGMP-dependent protein kinase Ialpha (cGK Ialpha), the downstream effector of cGMP signaling, blocked the activation of MAPK and prevented PDGF-directed VSMC migration. |
| 8 | 12176727 | Expression of antisense MKP-1 RNA prevented insulin's inhibitory effect and restored PDGF-directed VSMC migration and MAPK phosphorylation. |
| 9 | 12176727 | We conclude that insulin inhibition of VSMC migration may be mediated in part by NO/cGMP/cGK Ialpha induction of MKP-1 and consequent inactivation of MAPKs. |