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Gene Information
Gene symbol: DUSP6
Gene name: dual specificity phosphatase 6
HGNC ID: 3072
Synonyms: MKP-3, PYST1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FOXO1 | 1 hits |
| 2 | INS | 1 hits |
| 3 | PCK2 | 1 hits |
| 4 | PTPN1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11584002 | The combinatorial library/high-throughput screen protocols furnished a small molecule PTP1B inhibitor that is both potent (K(i) = 2.4 nm) and selective (little or no activity against a panel of phosphatases including Yersinia PTPase, SHP1, SHP2, LAR, HePTP, PTPalpha, CD45, VHR, MKP3, Cdc25A, Stp1, and PP2C). |
| 2 | 20921625 | In addition, we showed that PPAR? coactivator-1? (PGC-1?) acted downstream of FOXO1 to mediate MKP-3-induced gluconeogenesis. |
| 3 | 16126724 | The mitogen-activated dual specificity protein kinase phosphatase 3 (MKP-3) was identified as a candidate gene that antagonized insulin suppression on PEPCK gene transcription from this screen. |
| 4 | 16126724 | In addition, MKP-3 can activate PEPCK promoter in synergy with dexamethasone in hepatoma cells. |
| 5 | 16126724 | Furthermore, ectopic expression of MKP-3 in hepatoma cells by adenoviral infection increased the expression of PEPCK and G6Pase genes and led to elevated glucose production. |
| 6 | 16126724 | Therefore, dysregulation of MKP-3 expression and/or function in liver may contribute to the pathogenesis of insulin resistance and type II diabetes. |