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Gene Information
Gene symbol: EIF2AK3
Gene name: eukaryotic translation initiation factor 2-alpha kinase 3
HGNC ID: 3255
Synonyms: PEK, PERK
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATF6 | 1 hits |
| 2 | CALR | 1 hits |
| 3 | CANX | 1 hits |
| 4 | CASP12 | 1 hits |
| 5 | COMP | 1 hits |
| 6 | CYBA | 1 hits |
| 7 | EIF2AK2 | 1 hits |
| 8 | EIF2S1 | 1 hits |
| 9 | ERN1 | 1 hits |
| 10 | GCK | 1 hits |
| 11 | INS | 1 hits |
| 12 | NCF1 | 1 hits |
| 13 | NCF2 | 1 hits |
| 14 | PIK3CA | 1 hits |
| 15 | SDU | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10026192 | In contrast to PKR or HRI, which are dependent on autophosphorylation for their kinase activity, a point mutation that replaced the conserved Lys-614 with an alanine completely abolished the eIF-2alpha kinase activity, whereas the mutant PEK was still autophosphorylated when expressed in Sf-9 cells. |
| 2 | 11430819 | The protein kinase PERK couples protein folding in the endoplasmic reticulum (ER) to polypeptide biosynthesis by phosphorylating the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha), attenuating translation initiation in response to ER stress. |
| 3 | 15448106 | Permanent neonatal diabetes (PND) can be caused by mutations in the transcription factors insulin promoter factor (IPF)-1, eukaryotic translation initiation factor-2alpha kinase 3 (EIF2AK3), and forkhead box-P3 and in key components of insulin secretion: glucokinase (GCK) and the ATP-sensitive K(+) channel subunit Kir6.2. |
| 4 | 16246168 | Mice devoid of the eIF2 kinase GCN2 [general control non-derepressible-2 or EIF2AK4 (eIF2alpha kinase 4)] show sensitivity to nutritional deficiencies and aberrant eating behaviours, and deletion of PEK [pancreatic eIF2alpha kinase or PERK (RNA-dependent protein kinase-like endoplasmic reticulum kinase) or EIF2AK3] leads to neonatal insulin-dependent diabetes, epiphyseal dysplasia and hepatic and renal complications. |
| 5 | 20924496 | STZ was found to induce the characteristics of ER stress; mitochondrial Ca(2+) overloading, enhanced ER staining, release of glucose-regulated protein 78 (GRP78), phosphorylation of RNA-dependent protein kinase (PKR) like ER kinase (PERK) and eukaryotic initiation factor-2? (eIF-2?), cleavage of activating transcription factor 6 (ATF6) and caspase 12, and upregulation of CCAAT/enhancer-binding protein-homologous protein (CHOP). |
| 6 | 21029300 | This review highlights the particular importance of PERK-mediated translational control and the transcriptional response in pancreatic ?-cells and how these relate to the highly specialized function of ?-cells, namely glucose-regulated insulin secretion and production. |
| 7 | 20850340 | Genetic and cellular studies of Perk-deficient beta cells showed that PERK was crucially required for ER functions including proinsulin trafficking and quality control, unrelated to the ER stress pathway. |
| 8 | 21050479 | Wolcott-Rallison syndrome (WRS) is a rare autosomal recessive disease, characterized by neonatal/early-onset non-autoimmune insulin-requiring diabetes associated with skeletal dysplasia and growth retardation. |
| 9 | 21267711 | With a single injection of streptozotocin 65 mg/kg, ip in rats, early diabetic nephropathy was produced and revealed as an increased microalbuminuria, elevated creatinine and urea in serum, associated with upregulation of mRNA and protein of NADPH oxidase p22phox, p47phox, and p67phox and ET(A), upregulated PKR-like eukaryotic initiation factor 2? kinase (PERK), and downregulated Cx43 in the renal tissue. |
| 10 | 20922715 | All three regulate portions of the transcriptional unfolded protein response, while PERK also attenuates protein synthesis during ER stress and IRE1 interacts directly with the c-Jun amino-terminal kinase stress kinase pathway. |
| 11 | 20829802 | Deficiency of PERK attenuates FFA-induced activation of IKK? and deficiency of IKK? alleviates FFA-induced inflammation and insulin resistance. |
| 12 | 21345978 | The three major arms of the mammalian UPR include 1) protein kinase RNA (PKR)-like ER kinase (PERK), 2) inositol-requiring protein-1 (IRE1?), and 3) activating transcription factor-6 (ATF6) pathways. |
| 13 | 21345978 | The PERK pathway rapidly attenuates protein translation, whereas the ATF6 and IRE1? cascades transcriptionally upregulate ER chaperone genes that promote proper folding and ER-associated degradation (ERAD) of proteins. |
| 14 | 20349222 | However, the cytokine-induced ER-stress response in beta cells is atypical and characterised by induction of the pro-apoptotic PKR-like ER kinase (PERK)-C/EBP homologous protein (CHOP) branch of the unfolded protein response, but defective X-box binding protein 1 (XBP1) splicing and activating transcription factor 6 activation. |
| 15 | 21475143 | Examined were the effects of intravenously infused glucose and/or lipids on proximal ER stress sensor activation (PERK, eIF2-?, ATF4, Xbox protein 1 (XBP1s)), unfolded protein response (UPR) proteins (GRP78, calnexin, calreticulin, protein disulphide isomerase (PDI), stress kinases (JNK, p38 MAPK) and insulin signaling (insulin/receptor substrate (IRS) 1/2 associated phosphoinositol-3-kinase (PI3K)) in rat liver. |
| 16 | 21475143 | Glucose and/or lipid infusions, ranging from 23.8 to 69.5 kJ/4 h (equivalent to between ~17% and ~50% of normal daily energy intake), activated the proximal ER stress sensor PERK and ATF6 increased the protein abundance of calnexin, calreticulin and PDI and increased two GRP78 isoforms. |
| 17 | 21624209 | Wolcott-Rallison syndrome (WRS) is a rare autosomal recessive disorder characterized by the association of permanent neonatal or early-infancy insulin-dependent diabetes, multiple epiphyseal dysplasia and growth retardation, and other variable multisystem clinical manifestations. |