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Gene Information
Gene symbol: EIF2S1
Gene name: eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
HGNC ID: 3265
Synonyms: EIF-2alpha, EIF2A
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATF4 | 1 hits |
| 2 | EIF2AK2 | 1 hits |
| 3 | EIF2AK3 | 1 hits |
| 4 | EIF2B1 | 1 hits |
| 5 | HSPA1A | 1 hits |
| 6 | HSPA5 | 1 hits |
| 7 | INS | 1 hits |
| 8 | MAPK8 | 1 hits |
| 9 | NFKB1 | 1 hits |
| 10 | WFS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 1777648 | In other systems eIF-2B activity is regulated by phosphorylation of the alpha-subunit of a second initiation factor, eIF-2. |
| 2 | 8213069 | Here we report that the activity of eucaryotic initiation factor-2 (eIF-2), a protein that participates in the regulation of a rate-limiting initiation step of protein synthesis, transiently decreases following insulin-induced severe hypoglycemia in the rat brain neocortex. |
| 3 | 8213069 | We conclude that severe insulin-induced hypoglycemia induces a stress response in neurons in the recovery phase, including inhibition of protein synthesis initiation, depression of eIF-2 activity, and a delayed and prolonged expression of HSP 72 in surviving neurons. |
| 4 | 10026192 | In contrast to PKR or HRI, which are dependent on autophosphorylation for their kinase activity, a point mutation that replaced the conserved Lys-614 with an alanine completely abolished the eIF-2alpha kinase activity, whereas the mutant PEK was still autophosphorylated when expressed in Sf-9 cells. |
| 5 | 11430819 | The protein kinase PERK couples protein folding in the endoplasmic reticulum (ER) to polypeptide biosynthesis by phosphorylating the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha), attenuating translation initiation in response to ER stress. |
| 6 | 16246168 | Accompanying this general protein synthesis control, eIF2 phosphorylation induces translation of specific mRNAs, such as that encoding the bZIP (basic leucine zipper) transcriptional regulator ATF4 (activating transcription factor 4). |
| 7 | 16246168 | Reduced translation by eIF2 phosphorylation can also lead to activation of stress-related transcription factors, such as NF-kappaB (nuclear factor kappaB), by lowering the steady-state levels of short-lived regulatory proteins such as IkappaB (inhibitor of NF-kappaB). |
| 8 | 19190890 | In Wfs1 ( +/+ ) A ( y ) /a islets, levels of ER chaperone immunoglobulin-binding protein (BiP)/78 kDa glucose-regulated protein (GRP78) and phosphorylation of eukaryotic translation initiation factor 2, subunit alpha (eIF2alpha) apparently increased. |
| 9 | 19952270 | Palmitate treatment induced ER stress through a c-Jun N-terminal kinase (JNK)-dependent pathway because a selective JNK inhibitor blocked palmitate activation of the ER stress pathways eIF2 alpha and X-box binding protein-1. |