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Gene Information
Gene symbol: ENPP2
Gene name: ectonucleotide pyrophosphatase/phosphodiesterase 2
HGNC ID: 3357
Synonyms: ATX, PD-IALPHA
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | FURIN | 1 hits |
| 3 | INS | 1 hits |
| 4 | PLA2G4A | 1 hits |
| 5 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15700135 | The aim of the present study was to depict the physiopathological and cellular mechanisms involved in regulation of adipocyte autotaxin expression. |
| 2 | 15700135 | Autotaxin expression was up-regulated by treatment with TNFalpha (insulin resistance-promoting cytokine), and down-regulated by rosiglitazone treatment (insulin-sensitising compound) in 3T3F442A adipocytes. |
| 3 | 15700135 | Finally, adipose tissue autotaxin expression was significantly up-regulated in patients exhibiting both insulin resistance and impaired glucose tolerance. |
| 4 | 15700135 | The present work demonstrates the existence of a db/db-specific up-regulation of adipocyte autotaxin expression, which could be related to the severe type 2 diabetes phenotype and adipocyte insulin resistance, rather than excess adiposity in itself. |
| 5 | 15700135 | It also showed that type 2 diabetes in humans is also associated with up-regulation of adipocyte autotaxin expression. |
| 6 | 17208043 | In addition, N-glycosidase treatment and point deletion of the amino-acid N410 inhibits the lysophospholipase D activity of ATX. |
| 7 | 17208043 | Treatment of adipocytes with the furin inhibitor decanoyl-Arg-Val-Lys-Arg-chloromethylketone does not modified secretion or lysophospholipase D activity of ATX. |
| 8 | 17208043 | Transfection in Cos-7 cells of site-directed deleted ATX shows that the furin recognition site is not required for secretion or lysophospholipase D activity of ATX. |