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Gene Information
Gene symbol: F2RL1
Gene name: coagulation factor II (thrombin) receptor-like 1
HGNC ID: 3538
Synonyms: PAR2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | F10 | 1 hits |
| 2 | ING1 | 1 hits |
| 3 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19540892 | Protease-activated receptor 2 (PAR2) is a G-protein-coupled receptor that is proteolytically activated by certain endogenous proteases, such as trypsin, tryptase, and factor Xa. |
| 2 | 20972877 | Although vasodilation to the endothelium-independent vasodilator sodium nitroprusside (SNP) was not different among WT, db/db, db/db+FSLLRY-NH? and db(TNF-)/db(TNF-), endothelium-dependent acetylcholine (ACh)- and flow-mediated vasodilation were impaired in db/db mice but were enhanced in db(TNF-)/db(TNF-) mice and db/db mice treated with PAR2 antagonist. |
| 3 | 20972877 | PAR2-activating peptide (PAR2-AP, 2-Furoyl-LIGRLO-am)-induced dilation was higher in db/db mice than that in WT, db(TNF-)/db(TNF-) and db/db mice treated with PAR2 antagonist. |
| 4 | 20972877 | These results indicate that PAR2 plays a pivotal role in endothelial dysfunction in type 2 diabetes by up-regulating the expression/production of TNF-? and activating NAD(P)H oxidase subunit p47(phox). |
| 5 | 21628879 | The active type of coagulation factor X (factor Xa) activates various cell-types through protease-activated receptor 2 (PAR2). |